Congratulations to Ron as the winner of the Intel Xeon Workstation Sweepstakes. He has been a member of The Server Room for over a year and was able to complete the quiz on the first attempt. Good job! “I was excited to hear that I won the Intel Xeon workstation sweepstakes. With its incredible performance, the system offers me the flexibility to use it in so many ways that I’m not sure how to best utilize it at the moment. It’s a welcome problem to have and I look forward exploring the possibilities. Thanks to Intel and the Server Room team for providing a great resource to everyone!” Thank you all for entering and look for more sweepstakes offerings in the near future.- Your ‘The Server Room’ Admin’s
Nerve cell Gustavo Ayala has probed basic interactions between nerves and tumor cells that could lead to new therapies. Blood vessel Sympathetic nerves branching through the body release the hormone norepinephrine into nearby tissue. When it hits receptors on cancer cells, it can set off a signaling pathway that prompts growth. Green light for growth Norepinephrine released by nerves activates receptors on the endothelial cells that make up blood vessels. That signal prompts the formation of new blood vessels that can bring much-needed oxygen into a growing tumor. New blood Nerves can prompt certain immune cells to stand down. Some of their signals seem to nudgemacrophages into a mode that promotes cancer growth.They may also prevent T cells from attacking cancer cells directly. Extra protection Cancer cells release neurotrophicfactors—molecules that encourage nerves to branch and elongate toward the tumor. Luring nerves DWIGHT ANDREWS/MCGOVERN MEDICAL SCHOOL AT UTHEALTH Neurotrophicfactor How the body’s nerves become accomplices in the spread of cancer Tumor cells In 1998, Gustavo Ayala, a young pathologist, landed at Baylor College of Medicine in Houston, Texas, ready to start to see patients. But his state medical license was delayed, and during 4 months of unexpected freedom, he found himself hunched over lab dishes, absorbed by a strange kind of cellular courtship.Ayala hadn’t planned to do research full time, but a little-explored feature of cancer enticed him: the tendency of some cancer cells to wrap around nerves and grow along them. He had seen that “perineural invasion” in cancer patients and knew it often signaled an aggressive tumor and a poor prognosis. “But nobody knew how it happened,” Ayala says. “There was no biology.”So Ayala put spinal nerves from a mouse in a dish next to human prostate cancer cells. What he saw was a symbiotic dance: Before the cancer colony invaded the nerves, the nerves reached out to the cancer. They elongated toward the cancer cells and grew into the colony’s midst. In turn, the cancer cell colony ballooned. 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Those nerves churn out molecules that appear to aid the growth of cancer cells, and they alter surrounding tissue in ways that can make it more hospitable to cancer. “They’re not a bystander,” says Paola Vermeer, a cancer biologist at Sanford Research in Sioux Falls, South Dakota, who studies cancer-nerve interaction. “They’re an active participant in the disease process.”To some experts, those revelations from basic biology help explain a controversial link between chronic stress and cancer progression. The work has also prompted several clinical trials testing whether blocking nerve signaling slows tumors’ spread. Those studies have yet to show long-term benefits for patients, but optimism is high. “The field, I feel, is about to explode,” Vermeer says. “People are starting to take notice.” The field, I feel, is about to explode. People are starting to take notice. A dangerous partnership Recent studies have revealed many lines of communication between tumors, nerves, and other nearby cells. Their elaborate crosstalk seems to promote the growth and spread of cancer, in part through the release of stress-related hormones. Tumor By Kelly ServickSep. 12, 2019 , 10:35 AM It’s not outlandish to think the nervous system could become complicit in cancer’s growth and spread. Cancer is adept at exploiting the body’s normal functions—for example, by stimulating the growth of new blood vessels that nourish the invading cells. The disease manages to “curate the best of the body and use it to promote its survival advantage,” says Paige Green, head of the National Cancer Institute’s research program on basic biobehavioral and psychological sciences in Bethesda, Maryland. By studying how cancer “curates” protective mechanisms in the immune system, scientists have developed powerful drugs to thwart those mechanisms, sparking a multibillion-dollar industry.The role of nerves has taken longer to emerge, says cancer neurobiologist Hubert Hondermarck of the University of Newcastle in Australia. Before the development of precise ways to label neurons, the small nerve branches in and around tumors were easy to overlook. And even after those tools were available, “There was no particular interest in studying nerves in depth among the cancer community,” Hondermarck says.Many cancer labs were absorbed in studying genetic mutations in cancer cells themselves, not the body’s cancer-promoting signals, Ayala says. In the early 2000s, his focus on cancer-nerve crosstalk made him an outsider. “I was called the nerve guy.”But Ayala wasn’t truly alone. Others were studying nerves in hopes of pinning down an elusive connection between cancer and stress. One such researcher was Anil Sood, a cancer biologist at the University of Texas MD Anderson Cancer Center in Houston. He was intrigued by findings that tumors grew bigger and faster in lab animals that were stressed—for example, by being physically restrained or socially isolated. Some studies had even suggested chronic stress in people made cancer more likely to progress. But how those proposed links worked wasn’t clear, he says. Among researchers interested in stress and cancer, “There was a feeling that hardcore scientists would view these kinds of observations to be ‘soft science.’”So Sood and others went hunting for mechanisms. The researchers focused on the sympathetic nervous system, which orchestrates our “fight or flight” response to a perceived threat. The hormones epinephrine and norepinephrine play a key role in the response, increasing heart rate and blood pressure. Sympathetic nerves, which weave through our organs and signal to them, release those hormones into nearby tissue. (The adrenal glands perched on our kidneys secrete the same hormones into the bloodstream, which distributes them widely.)Many cells in the body, including many cancer cells, are studded with β-adrenergic receptors, to which epinephrine and norepinephrine bind. And activating those receptors on cancer cells seems to encourage them to grow. In 2006, Sood’s team reported it could prompt a mouse’s ovarian tumor to grow larger by either exposing mice to chronic stress or giving the animal a drug that activates β-adrenergic receptors. Both interventions prompted cancer cells to recruit and nourish nearby blood vessels that, in turn, fueled their growth. Blocking the receptors prevented this growth.That study and others showed cancer cells were alert to signals from the nervous system. Then, in 2013, research oncologist Claire Magnon and colleagues in the lab of cell biologist Paul Frenette at Albert Einstein College of Medicine in New York City went further. The researchers revealed that the small nerve fibers near a tumor were, at least sometimes, essential to the tumor’s growth. The team grafted human prostate tumors into mice and then either sliced out the surrounding nerves or destroyed them with a toxic chemical. Without neighboring nerves, the tumor failed to grow. In people, the team found that the higher the density of nerves in and around a prostate tumor, the faster the tumor tended to spread outside the prostate and the faster the cancer tended to recur after surgery. Studies by other groups showed that removing nerves could also prevent gastric and pancreatic tumors from forming. And at many other sites—including the breast, colon, and lung—researchers correlated nerve density with more aggressive disease. Norepinephrine They also began to document the ways that cancer and nerves cozy up. Nerves entwined in blood vessels can hitch a ride into a tumor as it recruits blood vessels to supply it with oxygen. Cancer cells also produce molecular signals that can prompt nearby nerves to form new projections snaking into and around the tumor. Some evidence suggests signals from cancer can even prompt the body to make brand-new neurons from stem cells.A provocative paper published in Nature this year showed that, in mice, neural precursor cells in the brain appear to migrate to a prostate tumor to supply it with neurons. The study, by Magnon, who is now at the French biomedical research agency INSERM in Paris, and collaborators, pointed to an unexplored path of communication between cancer and the central nervous system.Why would cancer cells form alliances with nerves in the first place, tuning in to their signals and drawing them close? One idea is that a nerve-rich neighborhood is simply a friendly place for cancer, says Steven Cole, a genomics researcher at the University of California, Los Angeles. Because nerves expand and migrate regularly, they crank out molecules that encourage growth and motility—which a nearby cancer cell will gladly drink up. Cole’s group also found that signals from sympathetic nerves nudge immune cells called macrophages to deconstruct nearby tissue, secrete growth-promoting molecules, and recruit blood vessels. “The cancer cells love it,” he says.Another idea is that listening to signals from sympathetic nerves helps cancer cells synchronize their invasion to periods of high stress, says neuroimmunologist Shamgar Ben-Eliyahu of Tel Aviv University in Israel. As cancer grows, it risks provoking T cells trained to attack and kill the body’s wayward cells, he explains. But when the body is on high alert and sympathetic nerves are most active, the immune system is tamped down. “If the tumor is smart enough to expose its cells to the immune system only when the immune system is suppressed, then it’s an advantage.”Some researchers view evidence about the role of nerves as a long-awaited mechanistic link between stress and cancer. “The idea that tumors can be so controlled by these nerves—all of a sudden it really brings some clarity into why various types of stress can be so bad for people,” says Elizabeth Repasky, a cancer researcher at Roswell Park Comprehensive Cancer Center in Buffalo, New York.Cole notes that when he and others talk of a cancer-promoting stress response, they don’t mean the psychological experience commonly referred to as stress. That fretful, frazzled mental state doesn’t align perfectly with the release of stress hormones into our tissues and veins, he says. Still, he and others believe a state of chronic threat or insecurity—when a person doesn’t know how to meet basic needs such as food, shelter, and companionship—can manifest in a physical reaction that may drive cancer.”I see these patients … who are taking care of their small children, maybe their parents, are living on aid or assistance, and now have some malignancy,” says Jennifer Knight, a psychiatrist specializing in cancer at the Medical College of Wisconsin in Milwaukee. “They’re in a chronic fight-or-flight mode because they’re under heightened threat, not getting basic needs met.” Knight is investigating whether stress-induced nerve activity could help explain why people of lower socioeconomic status do worse after a cancer diagnosis, even after factors such as access to care are controlled for.”There are still a lot of unknowns” about the stress-cancer link, Sood says. Nerve activity may promote cancer regardless of whether a person is under particular stress, he says, and nerves may be a driver only at particular stages in a tumor’s evolution.A fundamental problem, Hondermarck adds, is that objectively measuring the intensity of stress or defining what kind of stressful experience is relevant to disease is hard. “The potential relationship between stress and cancer has been in the air for a long time,” he says, “but has never been really demonstrated.”Regardless of the role of stress in cancer, targeting the nervous system with drugs might help treat the disease. Knight, Repasky, Frenette, and Sood are all investigating a common class of drugs called β blockers. Used since the 1960s to reduce blood pressure and treat cardiovascular disease, and sometimes prescribed to manage short-term anxiety, they block β-adrenergic receptors to keep heart rate low.Some retrospective studies have reported that people who happened to be diagnosed and treated for cancer while taking β blockers had better prognoses than patients not taking the drugs. But other studies found no benefit. So, several groups have launched prospective trials to test β blockers more systematically. Ben-Eliyahu has focused on the drugs’ potential to prevent metastasis after surgery, when residual disease often lingers around the surgical site or in distant parts of the body. He wondered whether administering a β blocker alongside another drug to reduce the cancer-promoting inflammatory reaction to surgery could make any leftover cancer less likely to spread.In 2017, his team published results from a clinical trial, conducted with Cole and other collaborators, that enrolled 38 women with breast cancer who were slated for surgery. Five days before the procedure, half started to take the β blocker propranolol and the anti-inflammatory drug etodolac. The study had too few participants to draw conclusions about survival or disease recurrence. But breast tumors from women getting the drug cocktail expressed fewer genes associated with metastasis than tumors of women taking placebo. Ben-Eliyahu says his group now has similar, unpublished results from 34 people with colorectal cancer. Macrophage Larger trials are in the works. Ben-Eliyahu and colleagues have launched a trial at Israeli medical centers that aims to recruit 210 people with pancreatic cancer, some of whom will start to take propranolol and etodolac a few days before surgery to remove their tumors. The researchers plan to track survival over 5 years.But the team is having trouble raising money for the trial, Ben-Eliyahu says. Other groups are struggling, too. “Those trials are really challenging for reasons that are incredibly annoying when you actually think about them,” Cole says: Industry sponsors don’t see a way to profit from drugs that long ago lost patent protection. “It’s hard to even recruit patients because their docs are all putting them on studies of these fabulously remunerative brand-new therapies, as opposed to this β blocker that my grandfather took when he had a heart attack or something,” he says.β blockers aren’t the only option for targeting the nervous system’s role in cancer. Future studies might also explore the potential of antibodies that bind to and disable proteins released by cancers that promote nerve growth, Hondermarck says. And Cygnal Therapeutics, based in Cambridge, Massachusetts, is pursuing cancer treatments that target the interaction between cancer and nerves, though it has yet to share details of its strategy.Two decades after his first curiosity project, Ayala—now at McGovern Medical School at the University of Texas Health Science Center in Houston—is still studying the cancer-nerve relationship and has begun to pursue possible therapies. Last year, his team reported in The Prostate that in four men with prostate tumors, injecting the nerve toxin botulinum into one side of the tumor prompted more cancer cells to die there than on the untreated side. He’s preparing to test the approach in a larger group of men.Ayala is energized by the new enthusiasm for the field. That he has had to spend some time in the academic wilderness is “absolutely normal,” he says. But in his view, studies focused on sympathetic nerves barely scratch the surface of cancer-nerve interactions. Some research has suggested a role for parasympathetic nerves, which counteract sympathetic signals to return the body to rest, and for sensory nerves, which relay various stimuli to the brain. Ayala is preparing to publish a study on the influence of two more nerve types, defined by the proteins they express. He expects that dozens of distinct nerve types form complex—and consequential—partnerships with cancer.”This is a story to be written by many people over the next 30 years,” he says. “There’s much more out there.”*Update, 13 September, 11:05 a.m.: This story was updated to mention Claire Magnon’s role in the 2013 study. C. BICKEL/SCIENCE Paola Vermeer, Sanford Research
Rafael Nadal of Spain shouts during his singles tennis match against David Goffin of Belgium at the ATP World Finals at the O2 Arena in London, Monday, Nov. 13, 2017. (AP Photo/Kirsty Wigglesworth)PARIS — Former French minister for health and sport Roselyne Bachelot was ordered to pay 10,000 euros ($11,800) in damages to Rafael Nadal on Thursday after accusing him of doping.In March last year, Bachelot said on a French television show that Nadal’s seven-month injury layoff in 2012 was “probably due to a positive doping test.”ADVERTISEMENT Nadal, who has won 16 Grand Slam titles, filed a defamation suit against Bachelot in Paris.The Spanish player said he will donate the money to a non-governmental organization or a foundation in France.“When I filed the lawsuit against Mrs. Bachelot, I intended not only to defend my integrity and my image as an athlete but also the values I have defended all my career,” Nadal said in a statement.FEATURED STORIESSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSPrivate companies step in to help SEA Games hostingSPORTSBoxers Pacquiao, Petecio torchbearers for SEA Games openingNadal said he wanted to keep public figures “from making insulting or false allegations against an athlete … without any evidence or foundation and to go unpunished.”He said the lawsuit was never motivated by money. MRT 7 on track for partial opening in 2021 Bachelot was also ordered by the French tribunal to pay Nadal a suspended fine of 500 euros ($590).In April 2016, Nadal wrote to the president of the International Tennis Federation asking for all of his drug-test results and blood profile records to be made public. In the same letter, he said of Bachelot: “It is unacceptable and mostly unfair that someone that should have knowledge of sports to a certain point and degree can publicly say something like this with no proof or evidence.”Sports Related Videospowered by AdSparcRead Next Ethel Booba on hotel’s clarification that ‘kikiam’ is ‘chicken sausage’: ‘Kung di pa pansinin, baka isipin nila ok lang’ Jordan delivers on promise: 2 Cobra choppers now in PH LATEST STORIES Kings of the NCAA Don’t miss out on the latest news and information. MOST READ The Fatted Calf and Ayutthaya: New restos worth the drive to Tagaytay Malditas save PH from shutout Robredo: True leaders perform well despite having ‘uninspiring’ boss PLAY LIST 02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games ‘A complete lie:’ Drilon refutes ‘blabbermouth’ Salo’s claims Hotel says PH coach apologized for ‘kikiam for breakfast’ claim After 30 years, Johnlu Koa still doing ‘hard-to-make’ quality breads View comments
PH military to look into China’s possible security threat to power grid SEA Games: PH still winless in netball after loss to Thais Hotel says PH coach apologized for ‘kikiam for breakfast’ claim LATEST STORIES Rugged, bumpy ride ends for Kia Sports Related Videospowered by AdSparcRead Next MOST READ ‘We cannot afford to fail’ as SEA Games host – Duterte BeautyMNL open its first mall pop-up packed with freebies, discounts, and other exclusives Robredo: True leaders perform well despite having ‘uninspiring’ boss PLAY LIST 02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games ‘A complete lie:’ Drilon refutes ‘blabbermouth’ Salo’s claims Don’t miss out on the latest news and information. Jordan delivers on promise: 2 Cobra choppers now in PH “I told them that if they can finish the game quickly while not acting too rash then do it, if they can build a lead and run away with it, then do it,” said Javier.“Our best set was the third because they did what I told them to do.”Arellano was well ahead late in the third set, 19-7, before the Lady Pirates tried to close in, thanks to a couple of lucky breaks that cut the lead to 19-9.FEATURED STORIESSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSBoxers Pacquiao, Petecio torchbearers for SEA Games openingSPORTSPrivate companies step in to help SEA Games hostingThe Lady Chiefs then scored five straight points before substitute Glydel Liu, who played only in the third set, finished the match with a well-placed kill.Arellano had four players scoring in double digits, led by Necole Ebuen who put up 11 points. Mary Esguerra, Andrea Marzan and Regine Arocha had 10 points each.Anne Romanban and Monica Sevilla produced eight points apiece for Lyceum, which dropped to 1-4. —BONG LOZADA, INQUIRER.NET Ethel Booba on hotel’s clarification that ‘kikiam’ is ‘chicken sausage’: ‘Kung di pa pansinin, baka isipin nila ok lang’ Defending champion Arellano stayed perfect in the NCAA Season 93 women’s volleyball tournament after a masterful 25-16, 25-17, 25-11 win over Lyceum on Sunday at Filoil Flying V Centre in San Juan.The Lady Chiefs rose to a league-leading 5-0 record as coach Obet Javier commended his wards for following their game plan to the letter.ADVERTISEMENT View comments
“The safety of our customers and crew is always our priority,” a British Airways spokesman said. “All customers have been provided with hotel accommodation, and our colleagues are helping them with anything further they require.” Jacob Steinberg, a Guardian sports reporter who was on the flight, said the captain told passengers there had been a “catastrophic” engine failure. “Just evacuated on a British Airways flight at Las Vegas airport after an engine caught fire. Dont think anyone hurt, he tweeted. “Was asleep as the plane took off. Came to a crashing halt. Smell of smoke. Initially told to stay seated, then shout of evacuate. “Could smell and see smoke but was on other side of plane. One person said fire melted a couple of windows. “They opened the back door and slide went down and smoke started coming in plane, followed by mad dash to front. A lot of panic.” PTI HSR NSA
On the field captain cool MS Dhoni has always lived up to his name. He has rarely been involved in heated exchanges. On several occasions he has openly criticized his teammates for playing the game with unstinting aggression.The Indian skipper, though, doesn’t disregard such on-field exchanges but said he always believed in staying within the rule during the pre-match press conference on Thursday.In what looks like a jibe at Virat Kohli’s aggressive display in the recently concluded Sri Lankan tour, Dhoni said, “Aggression need not mean exchanging words or physical contact.”Dhoni was quick to quote Rahul Dravid’s words that read, “aggression is like a good forward defense to a fast bowler.””It’s good to show intent, but at the same time you need to be in your guidelines. We have to make sure that everyone is available and that no disciplinary action needs to be taken against anyone,” Dhoni said.Speculation about Dhoni batting higher up the order is running rife ahead of the series. Dhoni, infact batted at No. 4 in Bangladesh and looked comfortable. Former skipper Sourav Ganguly in an exclusive interview to India Today voiced his support for Dhoni stepping in early.Dhoni himself said he would love to bat at No. 4 but said the batting order depends on the conditions and the match situation.”I would love to. We have to see the side composition, who is best suited to bat at what position,” Dhoni said.Also read: India get into T20 mode under Dhoni’s leadership advertisement “Most of our players are top-order batsmen, but when it comes to T20, they all bat at different positions. For example, Rohit opens the innings and Ajinkya Rahane is someone who bats middle order in ODIs and Tests but opens in IPL. So we have to see which individual is best at what position and based on that I’ll take the call.”Ahead of the World T20, Dhoni’s primary agenda would be zeroing in on a balanced batting line-up. He would be expected to shuffle the batting line-up after a few permutations and combinations.When it comes to his go-to-batsman Suresh Raina, Dhoni says he would prefer him coming at the fall of a wicket in T20s. He also hints at using him to serve the best interest of the team.”Raina is not a finisher. I don’t know whether it’s something good or bad that we play more IPL than T20 internationals, but if you notice carefully, he is somebody who has batted at No 3 throughout. But again, we have to place them strategically so that it serves the best interest of the team,” Dhoni said.Also read: Dhoni is a match winner, should bat higher up the order, says Ganguly When it comes to the bowling department, Dhoni has a problem of plenty. Three spinners, all of them eager to make a mark in the shortest format of the game, should give a lot of confidence to the captain. Dhoni has been a big fan of strangulating opposition with spin and India are well placed to create ample problems for the Proteas batsmen.Dhoni will also be pinning his hope on the four seam bowlers to get him early wickets. The conditions will play a huge role in choosing the right combination and Dhoni will hope for his men to deliver.Also read: Improved Sreenath Aravind raring to go against South Africa “We have four spinners, three proper seam bowlers and a seaming allrounder. So it gives you the luxury of going in with the right combination, depending on the scenario. Also, you have to see the strength of the team. If we go with two spinners, one of them has to be a better batsman. We don’t have a seaming allrounder, so that is another factors we have to keep in mind,” the skipper said.Switch from Tests to T20 is difficultDhoni called it quits from the longer format of the game in India’s tour to Australia in 2014. In spite of being a successful captain in shorter formats, he was not able to repeat his ODI heroics in the longer format. An array of away loses over a period of four years, since reaching the pinnacle of Test cricket, prove testimony to the fact. Dhoni’s inability to adapt to the longer format came under heavy criticism. He said getting the flow when making the switch from Tests to T20 was difficult.”I personally think changing guards from Tests to T20 is more difficult. Initially I believed it to be the other way around, reason being you can curb your instincts and everything. But when you move to the shorter format the game demands you to hit. For that, you want some kind of flow in your batting; you have to have that big swing but at the same time, not get carried away,” Dhoni said.advertisement
Peru Peru captain Guerrero to miss World Cup play-off after testing positive for banned substance Ryan Benson Last updated 2 years ago 06:44 11/4/17 FacebookTwitterRedditcopy Comments(0) Getty Images Peru New Zealand v Peru Peru v New Zealand Flamengo v Junior Junior v Flamengo New Zealand Flamengo WC Qualifying Play-Off CONMEBOL Sudamericana The 33-year-old will miss Peru’s crucial World Cup play-off with New Zealand after testing positive for a banned substance Peru captain Paolo Guerrero has tested positive for a banned substance and will miss his country’s World Cup qualifying play-off against New Zeland, the Peruvian Football Federation (FPF) has confirmed.Guerrero, 33, was selected for a mandatory doping test after Peru’s 0-0 World Cup qualifying draw with Argentina on October 5 and provided an irregular sample.The Flamengo star has been served with an initial suspension of 30 days by FIFA’s Disciplinary Committee and will miss the two crucial matches against New Zealand on November 11 and 16. Article continues below Editors’ Picks Lyon treble & England heartbreak: The full story behind Lucy Bronze’s dramatic 2019 Liverpool v Man City is now the league’s biggest rivalry and the bitterness is growing Megan Rapinoe: Born & brilliant in the U.S.A. A Liverpool legend in the making: Behind Virgil van Dijk’s remarkable rise to world’s best player He will also miss several matches at club level, with Flamengo involved in the semi-finals of the Copa Sudamericana against Junior Barranquilla of Colombia.Guerrero – who is Peru’s all-time leading scorer with 33 strikes – has seven days to respond, but could be forced into a lengthy absence if FIFA’s definitive results proving damning.The FPF made a statement confirming the news on Friday.It read: “The Peruvian Football Federation informs that, after the match played on October 5, 2017 against Argentina, Paolo Guerrero was subjected to an anti-doping control in accordance with the general protocol established in the preliminary stage of the competition Russia 2018.”Today [Friday], November 3, at 14:09 local time, the President of the FIFA Disciplinary Committee informed us of the provisional 30-day suspension measure of Paolo Guerrero for an adverse analytical result in the aforementioned control.”The FPF complies and respects this decision of FIFA and trusts that soon the facts are clarified and… this process is definitively resolved.”Paolo, captain and leader of our squad, plays a very important role for our squad on and off the pitch thanks to the quality of him as a person, which he has always showed.”We value his immense contribution to our selection, so the FPF and all of Peru has solidarity with him in these difficult moments.”
Transfers Coutinho, Aubameyang and the 20 most expensive transfers of January Chris Burton Last updated 1 year ago 16:00 2/1/18 FacebookTwitterRedditcopy Comments(1) Getty composite Transfers Premier League Liverpool Arsenal Chelsea Manchester City Barcelona Athletic Club Everton Tottenham Hotspur Southampton Borussia Dortmund Swansea City Monaco Stoke City Brighton & Hove Albion Valencia Bayern München Primera División Serie A Bundesliga Ligue 1 CSL The winter window is now closed, with the likes of Barcelona, Arsenal, Liverpool and Man City among those to have spent big bolstering their ranks
EUGENE, OR – OCTOBER 08: A general view during the game between the Oregon Ducks and the Washington Huskies on October 8, 2016 at Autzen Stadium in Eugene, Oregon. The Huskies defeated the Ducks 70-21. (Photo by Otto Greule Jr/Getty Images)One of the top wide receiver recruits in the country has named the top five schools in his recruitment.Johnny Wilson, the No. 2 wide receiver recruit in the 2020 class, took to Twitter this afternoon to list his top schools.The 6-foot-5 wide receiver is a Calabasas, California product, ranked the No. 18 overall prospect in the 2020 class by 247Sports’ Composite Rankings.Wilson’s top five schools are:WashingtonOhio StateTexasUCLAOregonHere’s his full announcement:You gotta tell The WIZRD, it’s a story like a book…✍? pic.twitter.com/EtDeCfmwXv— Johnny Wilson (@jjohnnywilson) January 28, 2019It’s unclear when Wilson will be making his decision. He’s already visited some of the schools on his list, including Oregon.From 247Sports:Wilson was one of the six five-star prospects on campus for the Ducks game against Washington, when Oregon upset the No. 7 Huskies in overtime.The 6-5, 215-pound wide receiver is the teammate of 2019 Oregon signee Mycah Pittman. During his junior season for Calabasas, Wilson totaled 31 receptions for 520 yards and 10 touchdowns. In his three years of varsity football, Wilson has 2274 yards and 35 receiving touchdowns. Wilson has already committed to play in the 2020 Polynesian All-American game.Stay tuned.
Three of the four early predictions in Collins’ 247Sports Crystal Ball are for Texas, with one for Texas A&M. However, recruiting is always fluid and some of those picks were entered in the fall.Still, the Longhorns appear to be firmly in the mix for the 6-foot-5, 247-pound star, who is the son of a former University of Texas women’s basketball player. Collins has made multiple trips to campus over the last year as well.He has already set one official visit, for Texas A&M the weekend of October 11.Collins was named District 13-5A-II Defensive Lineman of the Year in 2018. In earning the award, he stuffed the stat sheet, compiling 92 total tackles, 25 tackles for loss, six sacks, three forced fumbles, and two fumble recoveries. AUSTIN, TX – SEPTEMBER 6: An end zone pylon in a general view of Darrell K Royal-Texas Memorial Stadium before the BYU Cougars play the Texas Longhorns on September 6, 2014 in Austin, Texas. (Photo by Chris Covatta/Getty Images)Bastrop (Tex.) Cedar Creek four-star defensive end Alfred Collins announced his top five on Tuesday night. Texas remains in the mix.In addition to the Longhorns, Collins is considering Alabama, LSU, Oklahoma and Texas A&M. He is the No. 33 rising senior in the Lone Star State.Additionally, Collins is the 10th-ranked strong-side defensive end in the 2020 class according to 247Sports’ Composite Rankings.My top 5!!! pic.twitter.com/JT1H7zRiSl— alfred collins (@alfredcollins99) June 5, 2019
Editors’ Recommendations 9 Best Spirits For Spiked Apple Cider It’s Time to Ditch Your Sleeping Bag for a Versatile, Lightweight Camping Quilt Though there are a lot of materials that are well-suited for the frigid days of winter, but we’ve got a soft spot for one in particular: fleece, that napped, insulating fabric that’s unbelievably soft and warm at the same time. Used in gloves, jackets, sweaters, hats, pants, pajamas, hoodies, and blankets (to name just a few), fleece is as ubiquitous as the cold it actively fights against. To celebrate this versatile fabric, we thought we’d assemble some of our favorite fleece clothing for men. SweaterSynchilla Pullover from Patagonia – $119Perhaps one of the most well-known fleece accessories, the pullover makes for a fantastic cold weather go-to. Thrown over a flannel or cotton T-shirt, this everyday essential is warm and absolutely cozy. There are a lot of great options on the market, but we like this model from Patagonia, built with double-faced fleece and a wind-resistant collar.Shop NowSweatshirtClassic Sweatshirt from Todd Snyder – $98Soft, gentle, and unbelievably comfortable, few things in life feel better than a fleece sweatshirt. Not only does it help protect against the bitter cold, but also looks great paired with casual jeans and dressier chinos alike. One of our favorites is this sweatshirt from Todd Snyder, which features a classic silhouette done in soft stretch fleece.Shop NowPantsNorth Face Fleece Pants – $52To round out your all-fleece ensemble, make sure to snag a pair of fleece pants. Perfect for a quiet lounge around the house or a pre-dawn jog around the block, these bad boys are guaranteed to keep you smiling all winter long. We suggest grabbing this pair from North Face, whose midweight fleece is infused with moisture-wicking and quick-drying properties.Shop NowSocksPolar Feet Nordic Socks – $19While wool socks may reign supreme during wintertime, it’s important not to sleep on ones made of fleece. They’re equally as warm, yet much softer, working to envelop your cold and tired feet in a snuggly embrace. If you’re a fleece sock newbie, start by checking out this pair from Polar Feet, which come with special traction pads for easy mobility.Shop NowJacketWindproof Fleece Hunting Jacket from Orvis – $109If you spend a lot of time outdoors, you’ll definitely want to invest in a fantastic fleece jacket like this one from Orvis. Lightweight and durable, the sweater jacket is a pragmatic must-have that also happens to look pretty stylish. Plus, this particular model is built with wind-blocking technology, so could be especially good for blustery days.Shop NowVestFleece Vest from Columbia – $35Need something in between a sweater and a jacket for a crisp fall day? Consider wearing a fleece vest over a flannel shirt. It’ll keep your core nice and toasty without overheating the rest of your body, ensuring a wonderful sense of equilibrium. And when it comes to fleece vests, you can’t go wrong with one from Columbia.Shop NowGlovesMarmot Fleece Gloves – $25To cap off your fleece get-up, make sure to grab a pair of fleece gloves. While they may not be as good in snow as leather ones, they’re incredibly comfortable and work great as liners for other, sturdier gloves. We like this pair from Marmot, which comes with an advanced Falcon Grip for easy hand manipulation.Shop NowSlippersDouble Bottom Fleece Slipper from Minnetonka – $50And finally, why not do yourself a favor and buy a pair of fleece slippers? Cozy doesn’t even begin to cover how these slip-ons feel after a long day out in the cold or when you first hop out of bed in the morning. This season, we’re digging these slippers from Minnetonka, which feature a rubber sole, soft suede exterior, and sheepskin for extra comfort.Shop NowAnd speaking of slippers, if you’re looking for other options to keep your toes off the cold floor this winter, check out all of these slipper picks. How to Transition Your Wardrobe to Fall Banksy’s Gross Domestic Product Is a Pop-Up Shop Unlike Any Other The Ultimate Pillow Guide: The 6 Best Pillows for All Sleepers
zoom DP World has today welcomed the first scheduled vessel to call at its new Container Terminal 3 in Jebel Ali, Dubai, as it gears up to serve customers at the state-of-the-art facility. The first vessel to call at the port was ‘APL Phoenix’.“We are proud to welcome the APL Phoenix to Terminal 3 as trial operations begin at our newest terminal. As the USD 850 million Terminal 3 comes on line, it will support the growth of Dubai, the UAE and the wider region,” HE Sultan Ahmed Bin Sulayem, Chairman, DP World, said adding that Terminal 3 will be 30% more carbon efficient than a traditional terminal. Once fully operational next year, the container terminal will add a further 4 million TEU (twenty-foot equivalent container units) capacity to the port, taking total handling capacity at Jebel Ali to 19 million TEU. With its 21st century infrastructure and 18 metre draft, Terminal 3 gives Jebel Ali the ability to handle more of the new generation mega vessels, and as many as 10 Ultra Large Container Ships (ULCS) at the same time. Terminal 3 features 19 modern quay cranes remotely operated from a control room off the quayside. HE Sultan bin Sulayem said that Terminal 3 was built in direct response to the feedback from customers like APL “who told us clearly they needed more capacity at Jebel Ali. Shipping lines can now bring more of the world’s largest ships to our facilities and help improve the efficiency of the supply chain.”Press Release
zoom Containerized import volume continues to grow at the Port of Oakland, marking a 4% increase for the first 11 months of 2014, with a 2.97% increase in November, the third straight month of gains over last year.The port handled the equivalent of 771,454 20-foot import containers in the first 11 months of 2014, compared to 741,662 containers during the same period in 2013.The port attributed the increase to aggressive marketing, greater consumer demand and cargo diversions from congested Southern California ports. Through the peak shipping season, which concluded in November, thousands of imports rerouted to Oakland.Overall volume at the port – imports and exports – is up 1.5% in 2014. Exports have declined 4%. The port attributed the export drop to a strong dollar, which makes U.S. goods more expensive overseas. Exports have accounted for 54% of the port’s cargo volume in 2014 bolstered by a strong agricultural market.“Our objective is to make imports a bigger percentage of the cargo mix in Oakland,” said Maritime Director John Driscoll. “We’re progressing and the challenge now is to step up the pace in 2015.”
Coffee lovers, please take note. Drinking three or more servings of caffeinated beverages a day increases the risk of migraine. In a study, researchers evaluated the role of caffeinated beverages as a potential trigger of migraine. They found that, among patients who experience episodic migraine, one to two servings of caffeinated beverages were not associated with headaches on that day, but 3 or more servings of caffeinated beverages may be associated with higher odds of migraine headache occurrence on that day or the following day. Also Read – An income drop can harm brain”While some potential triggers may only increase migraine risk, the role of caffeine is particularly complex, because it may trigger an attack but may also help control symptoms, caffeine’s impact depends both on dose and on frequency,” said researcher from Harvard University. During the study, 98 adults with frequent episodic migraine completed electronic diaries every morning and every evening for at least six weeks. Every day, participants reported the total servings of caffeinated coffee, tea, soda and energy drinks they consumed, as well as filled out twice daily headache reports detailing the onset, duration, intensity, and medications used for migraines since the previous diary entry. Participants also provided detailed information about other common migraine triggers. Also Read – Shallu Jindal honoured with Mahatma Award”One serving of caffeine is typically defined as eight ounces or one cup of caffeinated coffee, six ounces of tea, a 12-ounce can of soda and a 2-ounce can of an energy drink. Those servings contain 25 to 150 milligrams of caffeine, so we cannot quantify the amount of caffeine that is associated with heightened risk of migraine. However, in this self-matched analysis over only six weeks, each participant’s choice and preparation of caffeinated beverages should be fairly consistent,” Mostofsky added.
Kolkata: Special Task Force (STF) of Kolkata Police has arrested a Jamaat-ul-Mujahideen Bangladesh (JMB) terrorist from Chennai on Tuesday morning. The JMB member has been identified as Asadullah Shaikh alias Raja of Nityanandapur at Bhatar in East Burdwan.According to sources, following the arrest of four JMB members, police were trying to locate other members of the banned terror outfit. A few days ago, STF officials came to know that one of the top JMB leaders was hiding somewhere in Chennai. Immediately, a team was sent to Chennai, who got in touch with the local police. Also Read – Bengal family worships Muslim girl as Goddess Durga in Kumari PujaOn Tuesday morning, police identified the hideout of Shaikh. Soon, the STF team along with the support of local police, raided the place at Nilangarai, Thoriyapakkam in Chennai and were able to nab him. He was produced before the Judicial Magistrate, Alamdur, with an appeal for transit which was eventually granted. The court has allowed three days transit remand for Shaikh to be produced at the Kolkata Court. During preliminary interrogation, police came to know that Shaikh had rented the house in Chennai in order to hide. He had fled from his house in Bhatar immediately after the Khargaragarh blast, which took place on October 2 in 2014. Also Read – Bengal civic volunteer dies in road mishap on national highwayPolice suspect that Shaikh was also involved in the Bodh Gaya blast. He was the closest person to JMB leader Kausar, who is one of the prime accused in the Khagragarh blast case. Kausar was arrested by the National Investigation Agency in August 2018 from Bengaluru. At that point of time, Shaikh was also hiding somewhere in South India. After the arrest of Kausar, he fled from his hiding place. Since then, Shaikh had taken shelter in Chennai and was living there. Locals in Bhatar claimed that before the Khagragarh blast they knew that Shaikh works in a brick manufacturing unit in Chennai. He used to come home once or twice a year.
Twitter Facebook LEAVE A REPLY Cancel replyLog in to leave a comment Advertisement The NFL, which sold the Canadian rights to the game, and CTV, which bought them and recoups the cost by selling domestic ads, vigorously opposed the move. OTTAWA—Former Republican presidential hopeful Marco Rubio is calling on the CRTC to allow Canadian ads to run instead of U.S. ads during the Super Bowl.The Florida senator is adding his voice to growing calls to Canada’s broadcast regulator to reverse its decision banning the substitution of Canadian ads over big-budget American spots during the NFL’s big game.Rubio, alongside fellow Republican Sen. Ron Johnson, has written to Canada’s ambassador in Washington urging Canada to change the policy. Advertisement Login/Register With: Advertisement The letter warns the decision sets a harmful precedent that could undermine Canada-U.S. relations.The Canadian Radio-television and Telecommunications Commission barred the airing of Canadian ads in place of American commercials in response to complaints from Canadian viewers.
Kolkata: An Assistant Sub-Inspector of police who came to Purulia from Siliguri, died in Purulia Sadar Hospital on Tuesday. The reason of his death is yet to be confirmed by the district police. According to the preliminary investigation it is suspected that the victim might have suffered a stroke due to excessive heat. Some of his colleagues said that the patient fell ill in the scorching summer heat. The doctors are yet to ascertain the actual cause of his death. The family members of the victim have been informed. Also Read – Bengal family worships Muslim girl as Goddess Durga in Kumari PujaIn another incident, a 40-year-old woman died at Bhagabanpur in East Midnapore, after she fell unconscious while taking rest on the side of a road. Local people found the woman lying unconscious under a tree. She was later rushed to a nearby hospital where the victim was declared brought dead. It is presumed that the patient might have survived if she was taken to the hospital on time. The hospital authorities are yet to confirm the exact cause of her death.
A deer carcass was left at the end of the driveway at a home on King Street in Tillsonburg in the early morning hours on April 9.The homeowners contacted police to report the mischief around 10 a.m. when they noticed the remains in the driveway.If anyone has any information that can assist with the investigation they are being asked to contact the Oxford County OPP detachment at 1-888-310-1122.
“The continued threat by the Lord’s Resistance Army (LRA) to regional stability should not be underestimated, in particular as the Ugandan and the South Sudanese forces have now disengaged from the African Union Regional Task Force (RTF), along with the United States special forces,” François Loucény Fall, the Special Representative and head of the UN Regional Office for Central Africa (UNOCA), told the Security Council. He explained that the Central African Republic national security forces, which could in the long run fill the gap left by the exit of the Ugandan forces, still require training and structural reforms. And the UN Multidimensional Integrated Stabilization Mission in the country, known by its French acronym MINUSCA, is not mandated to conduct anti-LRA military operations. Any training efforts would need to be in line with the overall security sector reform process and coordinated with other partners supporting the Central African armed forces, he added. “Collectively, there is a need to remain focused on efforts aimed at the total eradication of the LRA,” he said, stressing that UNOCA will remain engaged, including by reviewing the UN regional strategy to address the threat and impact of the LRA, and ensuring coordination among the various stakeholders working on the issue. His semi-annual briefing also touched on political tensions that have persisted in some Central African countries, mostly related to recent or future electoral processes, including Gabon and the Republic of the Congo. As for Lake Chad Basin, he said that the activities of the Boko Haram terrorist group have undermined development and exacerbated economic hardship in the region. Boko Haram remains a serious threat to regional stability despite the military progress achieved by the Multi-national Joint Task Force (MNJTF) against the terrorist group. In conclusion, he called for a strong commitment of the Security Council to the promotion of peace and security in Central Africa.
Mitchell H. Hooke, Chief Executive Officer of the Minerals Council of Australia (MCA) has said today that the “Australian Bureau of Agriculture and Resource Economics (ABARE) commodity forecasts further highlight the need for a fundamental re-think of the Federal Government’s proposed emissions trading scheme and workplace relations laws. Both will impact investment, competitiveness and employment at a time when more than 10,500 jobs have already been lost in the minerals sector as a result of the global recession.” The value of Australia’s minerals exports will fall by $35 billion in 2009-10, according to ABARE. Australia’s three most important minerals exports will contract sharply – coking coal exports are forecast to fall 42%, thermal coal 28% and iron ore 20%. According to the Hooke, this dramatic price slump will be compounded in 2010-11, when Australia’s coal, gold and iron ore producers face emissions trading permit costs of billions of dollars. In the first five years of the proposed ETS, Australia’s coal exporters alone face $5 billion in new carbon costs. None of their competitors in rich or poor nations will face such costs.ABARE’s report also highlights how other nations that don’t face carbon costs are gearing up production of key commodities. For example, Indonesia’s exports of thermal coal will reach 230 Mt in 2012, up 87% since 2005. The outlook is straightforward. Export returns are being slashed in an intensely competitive global commodities market. Hooke: “While other nations are gearing up, Australia is preparing to impose the world highest carbon costs on 90% of its minerals exports. The result is easy to predict – fewer jobs and projects in regional and remote Australia, but little if any environmental dividend.”Hooke: “A simple delay in the start of the ETS is not the answer. That would simply be a stay of execution for jobs and projects in the minerals sector. Our concerns with the ETS are that it is out of step with other world schemes, the deployment of low emissions technologies and the development of a global emissions protocol. The proposed workplace relations laws are also in need of fundamental change to ensure they are better aligned with the Government’s election mandate. The Fair Work Bill introduces new rights of entry and access to private records, establishes unions as the default bargaining agents and creates a platform for representational turf wars.”Hooke points out that “MCA members consider that key aspects of the new laws wind the industrial relations clock back to an era when workplaces were dogged by disputation and confrontation, when better pay and conditions were obtained through long-winded and often bitter arbitration and third parties external to the workplace had primacy over the concerns of the employee. It will unwind 25 years of industrial relations reforms spanning Governments of both political parties.” He concluded, “the ultimate cost of disruption in the workplace and new carbon costs will be jobs.”