Russian geneticist answers challenges to his plan to make gene-edited babies

first_img Denis Rebrikov says he’s planning to use the genome editor CRISPR on a gene whose protein is used by HIV to infect cells. Rebrikov, whose lab is in a busy in vitro fertilization (IVF) clinic, does not plan to repeat He’s experiment—he thinks its design was flawed. In He’s study, the Chinese researcher selected couples seeking IVF in which the male partner was infected with HIV. Although this by itself does not pose much risk for an IVF baby—the virus can be washed from sperm before injecting it into an egg—He said he wanted to “genetically vaccinate” the children against future risk of infection with the AIDS virus so they would not suffer the stigma and discrimination faced by their HIV-infected fathers.Rebrikov, in contrast, wants to find HIV-infected women who have had a “weak response to antiretroviral therapy,” as he explained in a paper he published last year in the Bulletin of Russian State Medical University (where he also works). The short paper describes his preclinical work using CRISPR and its Cas9 enzyme to modify CCR5 in nonviable human embryos.Rebrikov spoke with ScienceInsider yesterday about his plans, addressing the scientific arguments against his CCR5 target and specifics about his ultimate aims and the prospect of his controversial experiment moving forward. This is a condensed version of the conversation that has been edited for clarity. Q: In your paper, you cite two studies about pregnant, HIV-infected women who do not respond to antiretrovirals (ARVs). They’re both older studies with suboptimal drugs, and the women started treatment during pregnancy, which isn’t ideal. What current evidence is there that there are pregnant, infected women who fail all ARVs and transmit to their babies?A: We have about one woman in 30,000 to 40,000 of HIV-positive women who has no response on ARV therapy. They’re like multidrug-resistant people. We use different therapies and they still have persistence of HIV in the blood with a relatively high level. Nobody knows why it is. So this young woman who wants to get pregnant, she has a high risk of vertical transmission of the virus to the embryo. That’s the target group.Q: Russia has about 1 million infected people. That would mean you’re talking about 30 women in the country?A: Yes.Q: Only a subset of those want to get pregnant. What’s more, there’s been a steady introduction of new ARVs, and the new integrase inhibitors have extremely little evidence of people having drug resistance. Given that, what’s the rationale?A: CCR5 editing is just a proof of concept. If I can’t find an HIV-infected woman who doesn’t respond to ARV therapy and wants to be pregnant, I’ll look for different cases where both parents have a homozygous mutation for some genetic disease, like dwarfism, deafness, or blindness. We need models to start to use CRISPR embryo editing in clinical practice. I think we need several, 50, maybe 100 cases of using this technology, and after that we can we can try to use it more broadly. For example, we can see in a family that all babies will be born with a high risk of cancer. Now, when genome editing is just starting, it’s dangerous and not proven so we can’t use it with them. But in the near future, I think we can say to these parents, “Would you like to make some changes in the genome of your babies to reduce their risk of cancer?” And not only cancer, but different diseases like Alzheimer’s, Parkinson’s, and so on.Q: But returning to HIV, even if a mother receives no treatment, transmission in utero or at birth only happens about 15% of the time. Cesarean section lowers the risk even further. You can also reduce risk by giving the newborn a liquid dose of an ARV. CRISPR, on the other hand, could alter the genome in the wrong place, causing a dangerous off-target mutation. Some studies suggest crippling CCR5 could make people more susceptible to other diseases like West Nile or even shorten life spans. How do you balance this risk versus benefit equation?A: My experiment is concentrated on creating a system of genome editing that has no off-target activity. If we can convincingly show that there is no off-target activity in the genome, this system can be used in different types of genome editing. I have maybe a unique system, and maybe it’s possible only in Russia. I don’t know. Is it worth preventing some HIV transmission at the risk of decreasing longevity or putting people at risk of other diseases? It’s a philosophical question. Nobody knows the exact answer. It depends on a lot of factors.Q: Another risk is that you can only test a small percentage of the edited cells from an embryo before you implant it. [Embryos are sometimes “mosaic,” with different mutations in different cells.] There could be off-target edits that you can’t detect.A: Yes, the main problem is the mosaicism, because I can take only five, seven cells from the blastocyst’s 250 cells. So, we always have the risk that we check these five cells and find that everything is perfect, and then have problems in the other 200 cells.Q: In the Nature article, you said you could get approval in a few months to a few years. How does the approval process in Russia work? And what are the laws and regulations regarding germline editing?A: Approval from the government is not the biggest problem, it’s not the bottleneck. For me, the bottleneck is to find the correct clinical model. If I’ll find the good case, I think that we can get approval from regulators.Q: Let’s say you find that HIV-infected woman who wasn’t responding to any ARVs, wanted to get pregnant, and was willing to do this. How long will the approval process take?A: Maybe a couple of months.Q: Have you discussed it with regulators?A: We’ve just started to discuss it, and they say that if it will be a good clinical case, we can we can discuss it further.Q: In the United States, and in many other countries, there are actually laws that prohibit germline editing. Is there any such law in Russia?A: As far as I know, we don’t have direct restriction of such type of experiments, but usually Russia agrees with international rules. I know that transmission of germline-edited embryos into women is prohibited in most countries in Europe. In Russian law, we don’t have such language.Q: So you might face international regulations that prohibit you from doing what you want to do?A: I’m not a lawyer. So I don’t have an answer.Q: Two international committees are now discussing how to move forward with germline editing, and we also know the reaction to what He Jiankui did. If Russia went forward right now with this experiment, would those international considerations come into play? A: I don’t think it’s possible to restrict some experiments worldwide. You can try to restrict it in some areas, researchers can go to islands in the Pacific Ocean if they want to do it. We can’t stop progress with words on paper. So even if we say, let’s not do the nuclear physics, because it can make a bomb, a lot of scientists will still do this. We can’t stop it. A lot of groups will try to do experiments with embryos to transfer to women, and maybe it won’t be in my group, but we will see in the next years that they will have some results, and they will publish it. That’s maybe the problem for humans on the planet, that we cannot stop the progress.Q: What’s your clinic like?A: My lab is inside one of the biggest Russian obstetrics and gynecology center and we have about 10,000 IVF cycles per year.Q: What do you think of the harsh reaction to what He did?A: That’s a normal reaction of human population and all life systems, not only humans—maybe birds. Any life system, 90% of a population is very conservative. That’s normal. And maybe 5% is progressive. We just need to wait some time, maybe some years. And we need very good clinical cases to show people that this instrumentation is powerful, but it’s safe and has good results.Q: Do you think He has been treated too harshly? A: In Russia we have a phrase that if you have success, you are right. So if he is a lucky guy and these girls will be OK, in some years he will again be seen as a good researcher.Q: What was your reaction when you first learned what he did?A: It was positive. Actually, I don’t want to be the first. I want to transfer this technology in practice, and his experiment makes it closer to practice.Q: Do you expect that if you, too, go forward you will be intensely criticized?A: In Russia I think not so much. Internationally? I don’t want to move forward until I have approval from ethical committees and regulators, and I think it will not be as crazy as his steps.Q: Has anything happened since the Nature story appeared? Has any government official called you and said, “Stop this, don’t talk about this?”A: No. Russia now, I think, is a good country to do this type of experiments. It’s not very free in politics, but it’s very free in science.Q: What do you think of germline editing that’s not for disease, but for enhancement of things like running speed, IQ, or eye color?A: It will be the next step. But in 20 to 30 years. Now, I’m opposed to it. In 2040, I’ll support it. I’m not against the idea itself. And these people who are opposed want to have all these things in their children but only by “divine providence,” not by science. They are liars or stupid. By Jon CohenJun. 13, 2019 , 5:55 PM Denis Rebrikov/Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology Russian geneticist answers challenges to his plan to make gene-edited babies CC STUDIO/Science Source In a bold rejection of the widespread sentiment—and regulations in many countries—that no one should alter the genome of a human embryo and transfer it to a woman, Russian geneticist Denis Rebrikov last week went public with his plans to become the second researcher to cross this red line. “We can’t stop progress with words on paper,” Rebrikov told ScienceInsider yesterday, when asked about international efforts to ban such research.Rebrikov, who is at the Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology in Moscow, does not yet have Russian approval to do the experiment. But, as Nature first reported on 10 June, he would like to use the genome editor CRISPR to modify the CCR5 gene in embryos so they would be highly resistant to infection with HIV.This is the strategy that Chinese researcher He Jiankui attempted in a widely condemned experiment that led to the birth of twin girls. Jiankui, who did not publicly discuss his trial until news stories revealed details of it in November 2018, triggered an international push to step up oversight of human embryo studies that create heritable, DNA changes. Concerns about this so-called “germline editing” have led some prominent scientists to call for a moratorium. An expert committee at the World Health Organization and, separately, an international commission organized by academies of sciences have been convened to wrestle with the thorny question about how to create a framework that will responsibly move germline editing from the lab to the clinic.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*) A Russian biologist wants to use the in vitro fertilization clinic he works at to create more gene-edited babies.last_img read more

BCCI refuses to give 100 crore donation to CWG

first_imgGrappling with allegations of widescale corruption, the Commonwealth Games suffered another blow on Saturday with the Indian Cricket Board (BCCI) refusing to give a Rs 100 crore donation sought by the Oraganising Committee.After a meeting of its Working Committee at the Cricket Centre here, the BCCI said it would not be able to extend financial help to the October 3 to 14 event, the build-up to which has been marred by construction delays and now allegations of money laundering.”The Committee expressed its inability to agree to the request of the Commonwealth Games to be the lead partner by donating Rs 100 crores,” BCCI Secretary N Srinivasan said in a statement.Besides this, the Board also agreed to support New Zealand Cricket chairman Alan Isaac’s candidature for the ICC vice-President’s post.Isaac was picked after former Australian Prime Minister John Howard’s candidacy was rejected by the Afro-Asian bloc.”The Committee approved the candidature of Mr Alan Isaac, Chairman, New Zealand Cricket, for the post of ICC Vice-President,” the Board statement said.Among other issues, the BCCI said the stand-off over the contentious whereabouts clause of the World Anti-Doping Agency has been resolved.The Indian Board has roped in hockey legend Vece Paes as an anti-Doping Officer.”The Committee noted the satisfactory resolution to the WADA Anti-Doping issue, with the ICC. The Committee approved the proposal to seek the services of Dr Vece Paes, former Olympian, as Anti-Doping Officer. The modalities are being worked out,” the BCCI said.The Board also decided against giving the remaining Rs 12.5 crore of a Rs 25 crore grant requested by the All India Football Federation.advertisement”The money we have already given is given but we can’t pay the remainder because we no longer get concessions from the Income Tax Department,” a Board official said on the sidelines.The TV rights of the upcoming events were also discussed in the meeting.”Negotiations are on with Nimbus. The World Sports Group bid was not even opened,” the official revealed.The Board also approved advance grants of Rs 20 crore and Rs 25 crore respectively to the Mumbai Cricket Association and the Tamil Nadu Cricket Association for renovation of stadiums.last_img read more

World Cup: PM Modi hails Team India for fifth straight win

first_imgPM Narendra Modi presents a gift to his Australian counterpart Tony Abbott at a reception held in his honour at the Melbourne Cricket Ground in Melbourne in this file photo. Former Indian cricketers VVS Laxman, Sunil Gavaskar and Kapil Dev are with them. Photo: APPrime Minister Narendra Modi on Tuesday congratulated the Indian cricket team for registering its fifth straight win in the ongoing cricket World Cup.Shikhar Dhawan cracked a scintillating century as a rampaging India created a record winning ninth consecutive ICC Cricket World Cup match, including four in the previous edition, by demolishing Ireland by eight wickets to seal the top spot in the Group-B table.Superb all-round performance. Congrats Team India! Keep up the momentum.&; Narendra Modi (@narendramodi) March 10, 2015 In a message, Sports Minister Sarbananda Sonowal said: “Win against Ireland has once again proved that India’s consistently fine performance at the tournament is a matter of pride for all Indians.”He also congratulated Man of the Match Dhawan.Sonowal hailed skipper Mahendra Singh Dhoni for becoming the most successful captain for India in the history of the World Cup.Chasing a respectable Ireland total of 259, opener Dhawan (100 off 85 balls) sent the Irish bowlers on a leather hunt en route his eighth ODI hundred as the defending champions reached the target in 36.5 overs to record their fifth consecutive win in this tournament.last_img read more



More Paving Scheduled for Marine Drive

first_imgThe road along one of Nova Scotia’s most scenic shores will soon be an easier drive because of a tender announced by the Department of Transportation and Public Works. The tender is for repaving of Trunk 7 (Marine Drive) from the intersection of Dewolfes Road east for 10.2 kilometres to the intersection of the Mooseland Road. “We’ve been doing a lot of upgrading on Trunk 7 during the last few construction seasons,” said Angus MacIsaac, Minister of Transportation and Public Works. “This project will benefit residents and visitors.” The Department of Transportation and Public Works’ highways division manages more than 23,000 kilometres of roads in Nova Scotia. It maintains 4,100 bridges and operates seven provincial ferries. Staff provide services from district offices in Bridgewater, Bedford, Truro and Sydney.last_img read more

Calgary mayor says 2026 Olympic bid decision will be made by summer

first_imgPYEONGCHANG, South Korea – Thirty years after watching the opening ceremony at McMahon Stadium as a teenager, Calgary mayor Naheed Nenshi sat inside Olympic Stadium to watch the cauldron get lit here on Friday night.But he’s not just here as a fan of Team Canada.Nenshi is on a fact-finding mission in South Korea with a group that is publicly calling itself “an interested city” for the 2026 Winter Games – the formal International Committee nomenclature for those exploring their options to host, since bids are not yet open.“The real idea here is to have a bunch of meetings with both IOC people, but also the local organizing committee,” Nenshi told Sportsnet, in a wide-ranging interview Friday. “They’ve been real generous with their time to show some of the innovative things they’ve done with their venues, what they’re thinking of their legacy post-Olympics, just to give us a sense of how the Olympics have changed in the 30 years since Calgary ’88.”Calgary’s bid exploration committee forecasts the price tag for hosting both the 2026 Olympics and Paralympics to be $4.6 billion. Nenshi is here to get a first-hand look at how the PyeongChang Organizing Committee is executing its games, and to visit with the IOC on their commitment to keeping the endeavour financially feasible.“It’s a really good opportunity for us to spend some time with the International Olympic Committee to understand their games management system, the changes that they’ve promised to make to bring the cost of the games down and to really see how far that goes and if it really matches what Calgary, Alberta and Canada can do,” Nenshi said.It is expected the cost of just bidding to host an Olympics is in the $30 million range.“We will have to make a real decision if we’re serious about this by this summer,” Nenshi said.Earlier this week, in an address here in PyeongChang, IOC vice-president Juan Antonio Samaranch said the organization is in the “dialogue phase” with interested cities. It is not just Calgary that has serious questions about Olympic economics.“We are based on maximum flexibility, reduced cost, maximum use of existing facilities, sustainability, legacy,” Samaranch said. “The new norm is critical.”Which, in part, includes using – and renovating – existing venues, and finding ways to minimize capital costs for facilities. Prior to Friday’s opening ceremony, Nenshi attended Canada’s mixed doubles curling match and toured the multi-purpose facility that has been transformed into sheets of pebble for the next month. It’s a 3,500-seat arena that has practice sheets underneath.“It’s helpful to see how different people are approaching very similar problems,” Nenshi said.They were also studying PyeongChang’s transportation system, and how they shuttle thousands of people from the mountains to the coast – similar to how Calgary would have to get people to and from Banff and Canmore.Kirsty Duncan, Canada’s Minister of Sport and Persons with Disabilities, is here until Feb. 12. There is also a presence from the province of Alberta. Nenshi leaves next week.“Then we go back to our respective councils, caucuses, cabinets with what we’ve learned and really try to figure out if there is a financial and operating model that makes sense,” Nenshi said. “We have to go back to our citizens and discuss, while we’re still working on the technical feasibility of whether we can do it.”last_img read more

Manitoba animal rescue seeks help after dogs left behind in wildfire evacuations

first_imgWINNIPEG – An animal rescue organization in Manitoba has sent a letter to Indigenous Services Canada asking for help with hundreds of dogs left behind when two First Nations communities were evacuated last month due to fire.Debra Vandekerkhove, the director of Norway House Animal Rescue, estimates about 700 dogs — 200 in Pauingassi and 500 in Little Grand Rapids — were stranded after a wildfire forced about 1,400 people to flee.In the letter dated June 7, Vandekerkhove wrote that the situation for the dogs has become dire and, if left unchanged, will continue to deteriorate. Many younger dogs have already died and the ones left need to be removed, she said.There is also a concern that the dogs are forming larger, more aggressive packs.The Canadian Red Cross contacted the rescue group last week because the animals were running out of food. Vandekerkhove said arrangements have been made for more than 6,000 kilograms of food to be flown in, but there are few people in the communities who can distribute it.“They can’t keep up with the amount of dogs that need to be fed,” she said Friday.“We can’t get up there. We are not allowed because we are not a part of the emergency measures organization.”The Red Cross is working with Norway House Animal Rescue and the RCMP to distribute the food, said communications adviser Michelle Palansky in an email.Vandekerkhove said volunteers from the rescue group and from the First Nations would like to be temporarily flown back to help hand out food and to remove any pets that need veterinary help. But that needs approval and funding from the federal government, she said.The few people who have stayed behind have sent Vandekerkhove pictures of the dogs. Many show puppies that are gaunt and desperately eating the food that they find. There were dogs left without food or water for more than a week inside some homes, she said.Martine Stevens, spokesperson for Indigenous Services Canada, said the department is supporting the Red Cross in its efforts to help the animals. Offers of assistance are appreciated and “will be shared with First Nation leadership,” Stevens said in an email.The wildfire that blazed towards Little Grand Rapids, about 260 kilometres northeast of Winnipeg, forced hundreds of people in the fly-in community to huddle in a school gymnasium as they waited for the smoke to clear enough for planes to land.Initial reports said 11 houses were destroyed.There’s been no word on when people will be able to return.The situation is causing significant stress for the families who had to leave there homes, Vandekerkhove said.“It is traumatic and emotional for them. This is the one thing that’s left behind that is a living being that they are strongly connected to,” she said.“It’s important for their own emotional well-being that they know that their pets are going to be OK and there is somebody looking after them for them.”last_img read more

Kharge not to attend Lokpal selection panel meet

first_imgNew Delhi: Congress leader Mallikarjun Kharge has again rejected the government’s offer to attend a meeting of the Lokpal selection panel, saying there is no provision for a special invitee attending the meet. The meeting slated on Friday evening would be boycotted by Kharge the seventh time since February 2018. In a letter to Prime Minister Narendra Modi, the Congress leader alleged that the government has not made any attempt to amend the relevant provisions of the Lokpal Act to include the leader of the single largest party in the opposition as a member of the selection committee. “Since there is no provision under section 4 of the Lokpal Act, 2013, for a special invitee to be a part of the Selection Committee or attend these meetings, I am once again forced to respectfully decline this invitation,” he said in his letter. Kharge, as a leader of the Congress in the Lok Sabha, was earlier invited to attend the selection panel meetings six times and he has rejected the offers on the same grounds each time. He also alleged that the government and its ministers have repeatedly used his refusal to attend the meetings as a special invitee as an “excuse for not appointing a Lokpal over the last five years”. “However, the fact remains that whatever tardy progress the government has made has only been under pressure from the Supreme Court,” Kharge said. Alleging that “excluding the opposition”, this process is being “vitiated”, the Congress leader said, “I would like to caution the government that anyone selected through this one-sided process may decline to accept this position.”last_img read more

National Energy Board delays Trans Mountain expansion review deadline by nearly seven

VANCOUVER — A regulatory review of the proposed expansion of the Trans Mountain oil pipeline through British Columbia will be delayed by almost seven months while Kinder Morgan gathers information requested by the National Energy Board.The company now prefers a new route through Burnaby Mountain, in Metro Vancouver, and must complete further feasibility studies.Compiling the information could take an order from the National Energy Board that forces the City of Burnaby to co-operate.The city is officially opposed to the project that would almost triple the capacity of the existing Trans Mountain pipeline linking the Alberta oil sands to Port Metro Vancouver.Energy board spokeswoman Sarah Kiley says the company has until Dec. 1 to submit the requested studies to the board and then interveners will have until Feb. 3 to review and respond to that information.Under the original schedule, the board’s report was due July 2, 2015, but that deadline will now be Jan. 25, 2016.The Canadian Press read more

Smithermans husband found

Toronto police have confirmed they have found Christopher Peloso, the husband of George Smitherman.It is believed he was found near the train tracks at the train tracks Landsdowne and Dupont, and needed medical attention.39-year old Peloso was last seen Monday afternoon after leaving the couples home in mid-town Toronto.For six years he has been by the side of his husband former MPP and Mayoral candidate George Smitherman and at the home where they are raising two children.Smitherman ran against Toronto Mayor Rob Ford in the 2010 election.When news of the disappearance became known other prominent politicians took to Twitter. Provincial NDP leader Andrea Horwath wrote: Wishing strength to G Smitherman and his family at what must be a difficult time, hoping for a safe return. Federal Liberal Leader Justin Trudeau wrote: Thoughts and prayers to G Smitherman. 00:00:00 | 00:00:00::Projekktor V1.3.09 read more

Strong demand for vans continues to carry commercial vehicle market

Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window) Commercial vehicle market grows 11.9% in August, increasing registrations to 214,959 for the year-to-date, up 13%.Continued growth seen in van market; up 22.3% in August and 19.1% to 192,948 units for the year-to-date.Truck registrations down 22% for the year-to-date, with a fall of 22.7% in August continuing the trend. Rolling year totals remain strong, up 12.9%, fuelled by the rush in late 2013 for pre-Euro-6 vehicles.UK van and truck registrations: 2014 and % change on 2013“Strong van registrations have led to another month of continued growth for the commercial vehicle market, with the demand for light commercial vehicles continuing to build,” said Mike Hawes, SMMT Chief Executive. “The truck market is still seeing the effects of a particularly strong end to 2013 ahead of the introduction of Euro-6. Stability will return to the market, although expectations for the year remain subdued.”Van and truck registrations – rolling year trends Jan 2010 to date Click through to download the full August 2014 commercial vehicle news release and data tables. read more

Gallery Mens Basketball at Indiana

The Ohio State Men’s Basketball team played Indiana on Feb. 10 at Simon Skjodt Assembly Hall in Bloomington, Ind. Ohio State won 55-52. Photos by Casey Cascaldo Ohio State sophomore forward Kaleb Wesson (34) and Indiana sophomore forward Justin Smith (3) reach for the jump ball as the Ohio State-Indiana game begins on Feb. 10. Ohio State won 55-52. Credit: Casey Cascaldo | Photo Editor

Alen Muratovic is back to handball

Alen MuratovicASOBALcangasSG Flensburg One of the best left back in Europe five-six years ago, Alen Muratovic (34) will again play handball after he decided to stop professional career due shoulder injury in 2010! TOP performances during his time in BM Valladolid and the best result in the club history when Spanish team played in EHF CL semi-final in 2007, was the main reason why Muratovic’s transfer to SG Flensburg in 2008 was payed 700.000 EUR! That was the biggest transfers in the history of German Bundesliga before deals of Domagoj Duvnjak (HSV) and Daniel Narcisse (THW Kiel).Unfortunately, in January 2009 during friendly match, Muratovic was seriosly injured and after 18 months, surgery and recovery period, he announced end of professional career because of his shoulder injury. That was a hard decision, but health had priority.Three years after, ex-Montenegrian left back decided to try to get back to handball. He will play for ASOBAL member, Cangas, the 14th team in the last Spanish championship. Hopefully, his shoulder won’t be such a problem.Good luck Alen! ← Previous Story VfL Gummersbach got a new home – Schwalbe Arena is open! Next Story → Danil Chernov to SL Benfica read more

Zuckerberg Eisenberg Appear on SNL

first_imgAlso, Samberg. That last one’s not really that weird, though–he’s actually on the show. You’ve got to hand it to Mark Zuckerberg, he’s a pretty good sport, appearing on this weekend’s Saturday Night Live, alongside Jesse Eisenberg, who played a decidedly unflattering–but Academy Award nominated–version of the kid billionaire in last year’s The Social Network. Samberg and Eisenberg both showed off their versions of the Facebook founder. Eisenberg: “I speak in short, clipped sentences and keep my head very still.” Samberg: “I wear this sweatshirt.” Zuckerberg joined the two on stage for an encounter Samberg (on script) called, “Awkberg.”And yes, yes it was. For all of us. It wasn’t one of those “hey, look what they did” monologues, not one of the especially hilarious variety. Zuckerberg, let’s be honest, has the acting chops and comedic timing of fellow billionaire Steve Forbes. But that’s not the point. The point is, the guy’s a good sport. Also, he invented poking.Video after the jump.last_img read more

Here are the 10 tunes shortlisted for Irish song of the year

first_img Wednesday 1 Feb 2017, 9:22 PM Feb 1st 2017, 9:22 PM Short URL 19,498 Views Here are the 10 tunes shortlisted for Irish song of the year The shortlist for the RTÉ Choice Irish song of the year has been announced. The RTÉ Choice Music Prize has entered its 12th year running.People are able to vote for their favourite song through the website.Voting closes at midnight on Sunday 5 March. The winning song will be announced at the RTÉ Choice Music Prize live event, held in Vicar Street, Dublin on Thursday 9 March.An event is being held tonight in the Workman’s Club in Dublin to celebrate the shortlist being released.The winning act will receive €10,000, a prize fund which has been provided by The Irish Music Rights Organisation (IMRO) and The Irish Recorded Music Association (IRMA)RTÉ released the shortlist for the Irish Album of the Year last month.Read: These were the 10 best albums in Ireland last year*center_img Source: IMRO via TwitterTHE SHORTLIST FOR the RTÉ Choice Irish song of the year has been announced.The list features high profile top Irish acts as well as some lesser known ones.Niall Horan, Raglans, Walking on Cars and The Coronas all feature this year round.The list in full is:The Coronas – What a love (Island)Hare Squead – If I Ask (Sony)Heroes in Hiding – Hospital (Self Released)Niall Horan – This Town (Capitol)James Vincent McMorrow – Rising Water (Faction)Picture This – Take my Hand (Warner Music)Raglans – Who Knows (Self Released)Saint Sister – Tin Man (Communion)Soulé – Love No More (Diffusion Labs)Walking on Cars – Ship Goes Down (Virgin/EMI) Share21 Tweet Email2 By Cormac Fitzgerald 20 Comments Tweet thisShare on FacebookEmail this articlelast_img read more

Hors du Japon les radiations de Fukushima auraient un faible impact selon

first_imgHors du Japon, les radiations de Fukushima auraient un faible impact selon l’OMSUn rapport de l’Organisation Mondiale de la Santé (OMS) indique que les doses de radiations dont le Japon a été victime suite à la catastrophe de Fukushima sont très faibles. Elles se situeraient en-dessous des seuils autorisés.Le rapport de 120 pages, diffusé hier à Genève par l’Organisation Mondiale de la Santé (OMS), affirme que les doses de radiations provenant de Fukushima ont eu un faible impact. Pour cela, l’organisme s’appuie sur des mesures officielles et sur des simulations menées par ordinateur. Toutefois, ce document ne tient pas compte des personnes qui ont été évacuées de la zone proche de la centrale nucléaire ni des travailleurs qui nettoient le site.À lire aussiMaladie de Charcot : symptômes, causes, traitement, où en est on ?En effet, les localités de Namie et Itate qui se situent dans la zone interdite (dans un rayon de 20 à 30 kilomètres autour de la centrale) ont été fortement touchées avec des doses allant de 10 à 50 millisieverts (mSv), soit beaucoup plus que les doses de 1 à 10 relevées ailleurs dans la préfecture et de 0,1 à 10 dans les régions voisines. Sans tenir compte de ces éléments, le rapport estime donc que l’impact pour le reste du monde est estimé à 0,01 mSv, soit un niveau “très faible”. “Il peut être conclu que les doses estimées à l’extérieur du Japon sont en dessous (et souvent très en dessous) de doses considérées comme très faibles par la communauté en charge de la protection radiologique”, indique l’OMS.Le groupe de travail qui a rédigé ce rapport estime également que, plus d’un an après la catastrophe (mars 2011), les doses de radiations seront certainement inférieures à celles de Tchernobyl survenue en Ukraine en avril 1986. Le document constitue une partie d’un rapport plus large qui sera prêt cet été et qui vise à déterminer les conséquences de l’accident de Fukushima dans le domaine de la santé. Le 25 mai 2012 à 19:19 • Maxime Lambertlast_img read more

Swedish Battery Breakthrough Could Boost A Teslas Range By 70

first_imgStay on target Keto Turns Your Smartphone Into Your Car KeysAston Martin Will Build You Your Very Own Supervillain Lair The Tesla Model 3 can drive for about 220 miles on its sizeable battery pack. The extended range option pushes that all the way to 310 miles. New battery tech could boost those numbers by another 70%.That’s a massive increase in range that would see the base Model 3 rolling for nearly 375 emission-free miles and the extended range smashing the 500-mile mark. And it could be a reality very soon thanks to new battery packaging tech that’s been developed in Sweden.Christine Lampe-Önnerud and Cadenza Innovation have been working for the past four years on something she described to Business Insider as “an energy Lego brick for engineers.”Cadenza has created a “new way to package energy.” Their design allows the cells to be packed more tightly inside a special ceramic casing. That, in turn, is wrapped in aluminum which provides additional protection and acts as a big heat sink. The result, Lampe-Önnerud says, is a battery pack that’s much more energy-dense.With a stack of freshly-approved patents in hand, Cadenza is now ready to start making deals. Tesla is definitely on the company’s radar, and they’ve had talks, but Elon Musk and Co. are focused on meeting delivery goals right now. The timing isn’t right to introduce a major new technology, according to Lampe-Önnerud.She’s quick to add that Cadenza has spoken to every major player in the EV game and they’re all very interested. And, like Tesla, Cadenza isn’t limiting its battery design to the automotive sector.They’re also pitching it as a way to improve and stabilize the energy grid. A demo project in The Big Apple is already being discussed.Let us know what you like about Geek by taking our survey.last_img read more

Poway synagogue shooting suspect indicted on 113 federal charges

first_imgPoway synagogue shooting suspect indicted on 113 federal charges Posted: May 21, 2019 Updated: 3:32 PM May 21, 2019 KUSI Newsroom, center_img SAN DIEGO (KUSI) – A man accused of opening fire inside a Poway synagogue, killing a woman and injuring three other people, was indicted by a federal grand jury Tuesday on 113 federal counts related to the shooting, as well as the alleged arson of an Escondido mosque.John T. Earnest, 19, is accused of the April 27 shooting at Chabad of Poway and the March 24 fire set at the Dar-ul-Arqam Mosque, also known as Islamic Center of Escondido.The indictment added four counts of using and carrying a firearm during and in relation to a crime of violence, which were not included in the original federal complaint filed earlier this month.He is being charged by both federal and state prosecutors and faces a possible death sentence in both cases. Neither office has made a decision regarding whether to pursue the death penalty.Earnest is slated to be arraigned on the new indictment on June 4.The defendant is accused of carrying out the shooting on the last day of Passover, killing Lori Gilbert Kaye, 60, who was shot twice in the synagogue’s foyer and died at a hospital.The congregation’s rabbi, Yisroel Goldstein, 57, lost a finger in the shooting. Two other people — Almog Peretz, 34, and his 8-year-old niece, Noya Dahan — were also injured.Authorities said Earnest, who lived with his parents in Rancho Penasquitos and was studying nursing at Cal State San Marcos, confessed to both the shooting and the arson fire in an online manifesto posted prior to the synagogue shooting.He faces 113 federal counts total, which includes the four new counts, 54 counts of obstruction of free exercise of religious beliefs using a dangerous weapon, resulting in death, bodily injury and attempts to kill; 54 counts of hate crimes in violation of the Matthew Shepard and James Byrd Jr. Hate Crimes Prevention Act; and one count of damage to religious property by use of fire.Each of the 54 hate crime and obstruction of free exercise of religious beliefs counts apply to congregants who were inside the synagogue during the shooting rampage, U.S. Attorney Robert Brewer said. Of that number, 12 are children, he said.Earnest is also charged in state court with murder, attempted murder and arson. His next hearing in the state’s case is a readiness conference set for May 30.Kaye, a longtime member of Chabad of Poway, was at the temple with her physician husband and daughter the day of the shooting to honor her mother, who recently died. The congregation’s longtime rabbi lost his right index finger in the shooting. Peretz was shot in a leg while shepherding children to safety. His niece was struck by shrapnel in her face and leg.An off-duty Border Patrol agent working as a security guard was inside the temple when the shooting began, and he opened fire as the suspect fled, San Diego County Sheriff Bill Gore said. The agent did not strike Earnest, but did hit the suspect’s car, authorities said.Police said Earnest called 911 at around 11:30 a.m. and said he had been involved in the shooting and was armed.According to the federal complaint, Earnest told a dispatcher, “I just shot up a synagogue. I’m just trying to defend my nation from the Jewish people … They’re destroying our people … I opened fire at a synagogue. I think I killed some people.” He allegedly added that he shot up the synagogue “because the Jewish people are destroying the white race.”A San Diego police officer who had been en route to the synagogue spotted the suspect’s Honda Civix and pulled him over at 17051 W. Bernardo Drive, less than two miles west of the synagogue, Deputy District Attorney Leonard Trinh said. Earnest got out of his car with his hands up and was taken into custody without further incident.In the “open letter” that authorities say Earnest posted online shortly before the shooting, the author espouses flagrant anti-Semitic sentiments and a need to protect the “European race.” He wrote that he spent four weeks planning the attack, citing his “disgust” for Jews and a desire to kill them, and expressed admiration for the Australian white nationalist who attacked two mosques in Christchurch, New Zealand, in March, killing 50 people.The writer also claimed responsibility for the March 24 blaze set at the Dar-ul-Arqam Mosque in Escondido. The 3:15 a.m. fire was quickly extinguished by people inside the mosque. Graffiti left on the building made reference to the mosques attacks in Christchurch.Surveillance footage allegedly captured a suspect arriving at the mosque in the same type of vehicle in which Earnest was captured on the day of the synagogue shooting. KUSI Newsroom Categories: California News, Local San Diego News FacebookTwitterlast_img read more

Hong Kongs Far East Consortium reports first full year gaming revenue after

first_img RGB expecting strong 2019 despite second quarter revenue, profit decline Load More RelatedPosts Jeju gaming decline sees Landing International fall into loss in 1H19 Hong Kong property giant Far East Consortium (FEC) has reported revenue from gaming operations of HK$259.3 million (US$33.2 million) for the 12 months to 31 March 2019 – the first year in which it has generated income from the segment. Segment profit for the year was HK$72.0 million (US$9.2 million).The revenue figure includes HK$196.9 million from its European operations following the April 2018 acquisition of Trans World Corp, which owns and operates three casinos in the Czech Republic bordering Germany and Austria. South Korea’s foreigner-only casinos see revenues grow in August The remaining HK$62.4 million represents FEC’s dividend from its investment in Star Entertainment Group following the acquisition of a 4.99% stake in March last year. Star Entertainment Group operates The Star Sydney and The Star Gold Coast, and is developing the AU$3.2 billion Queen’s Wharf project in Brisbane.FEC’s property development arm is also interested in residential tower developments at both The Star Gold Coast and Queen’s Wharf Brisbane with the company stating that the combined attributable Gross Development Value of these assets was expected to be around HK$7.36 billion (US$941 million).FEC group revenue for FY19 across all segments grew 17.3% to HK$6.84 billion with net profit attributable to shareholders of the company rising 8.6% to HK$1.71 billion. The company has recommended a final dividend of HK$0.18 cents.last_img read more

Xiaomi Faces Threat from Counterfeits

first_imgChinese smartphone maker Xiaomi Corp. is facing increasing threat from counterfeits hitting its sales, as fake products flood the markets both inside the country and abroad.The company could sell only 14.6 million units of Mi Power Bank battery pack for smartphones last year, less than half of what it should have been, Bloomberg said quoting Xiaomi’s CEO Lei Jun.”What is the biggest problem? There are many fakes,” Lei said, adding, “If there were no counterfeits, our sales would be double or triple. The product has been recognized by everyone.”Revenue loss to Xiaomi as a result of counterfeits to Mi Power Bank is projected to be atleast $115 million. The company sells at least three variants of the Mi Power Bank in China, priced in a range of about $7.90 to $21.Founded in 2010, Xiaomi witnessed rapid growth to emerge as the top smartphone vendor in China, the world’s second largest smartphone market. Valued at about $45 billion, Xiaomi is regarded the most valuable start-up globally.The company’s smartphone shipments more than tripled to 61.1 million units last year with revenues seeing a two-fold increase. Xiaomi’s sales are estimated to increase to 120 billion yuan ($19 billion) in 2015, up from 74.3 billion yuan last year, Lei said.Markets in China “facilitate the distribution of significant quantities of counterfeit merchandise for consumption in China and abroad,” the office of the US Trade Representative said in its review of “Notorious Markets” released on 5 March this year.This prompted China’s Vice Premier Wang Yang to assure that his country will increase efforts in 2015 to take on the growing menace of piracy and counterfeiting.last_img read more