Chili pepper cocktail points to wide-awake surgery

first_imgImagine an epidural or a shot of Novocain that doesn’t paralyze your legs or make you numb yet totally blocks your pain. This type of pain management is now within reach. As a result, childbirth, surgery, and trips to the dentist might be less traumatic in the future, thanks to researchers at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS) who have succeeded in selectively blocking pain-sensing neurons in rats without interfering with other types of neurons.The pint-sized subjects received injections near their sciatic nerves, which run down their hind limbs, and subsequently lost the ability to feel pain in their paws. But they continued to move normally and react to touch. The injections contained QX-314, a normally inactive derivative of the local anesthetic lidocaine, and capsaicin, the active ingredient in hot peppers. In combination, these chemicals targeted only pain-sensing neurons, preventing them from sending signals to the brain.“We’ve introduced a local anesthetic selectively into specific populations of neurons,” explains HMS Professor Bruce Bean, an author on the paper, which appears in Nature today (Oct. 4). “Now we can block the activity of pain-sensing neurons without disrupting other kinds of neurons that control movements or nonpainful sensations.”“We’re optimistic that this method will eventually be applied to humans and change our experience during procedures ranging from knee surgery to tooth extractions,” adds Clifford Woolf of MGH, who is senior author on the study.Despite enormous investments by industry, surgical pain management has changed little since the first successful demonstration of ether general anesthesia at MGH in 1846. General and local anesthetics work by interfering with the excitability of all neurons, not just pain-sensing ones. Thus, these drugs produce dramatic side effects, such as loss of consciousness in the case of general anesthetics or temporary paralysis for local anesthetics.“We’re offering a targeted approach to pain management that avoids these problems,” says Woolf.The new work builds on research conducted since the 1970s showing how electrical signaling in the nervous system depends on the properties of ion channels, that is, proteins that make pores in the membranes of neurons.“This project is a perfect illustration of how research trying to understand very basic biological principles can have practical applications,” says Bean.The new method exploits a membrane-spanning protein called TRPV1, which is unique to pain-sensing neurons. TRPV1 forms a large channel, where molecules can enter and exit the cell. But a “gate” typically blocks this opening. The gate opens when cells are exposed to heat or the chili-pepper ingredient capsaicin. Thus, bathing pain-sensing neurons in capsaicin leaves these channels open, but nonpain sensing neurons are unaffected because they do not possess TRPV1.The new method then takes advantage of a special property of the lidocaine derivative QX-314. Unlike most local anesthetics, QX-314 can’t penetrate cell membranes to block the excitability of the cell, so it typically lingers outside neurons where it can’t affect them. For this reason it is not used clinically.When pain-sensing neurons are exposed to capsaicin, however, and the gates guarding the TRPV1 channels disappear, QX-314 can enter the cells and shut them down. But the drug remains outside other types of neurons that do not contain these channels. As a result, these cells fully retain their ability to send and receive signals.The team first tested the method in a Petri dish. Alexander Binshtok, a postdoctoral researcher in Woolf’s lab, applied capsaicin and QX-314 (separately and in combination) to isolated pain-sensing and other neurons and measured their responses. Indeed, the combination of capsaicin and QX-314 selectively blocked the excitability of pain-sensing neurons, leaving the others unaffected.Next, Binshtok injected these chemicals into the paws of rats and measured their ability to sense pain by placing them on an uncomfortable heat source. The critters tolerated much more heat than usual. He then injected the chemicals near the sciatic nerve of the animals and pricked their paws with stiff nylon probes. The animals ignored the provocation. Although the rats seemed immune to pain, they continued to move normally and respond to other stimuli, indicating that QX-314 failed to penetrate their motor neurons.The team must overcome several hurdles before this method can be applied to humans. They must figure out how to open the TRPV1 channels without producing even a transient burning pain before QX-314 enters and blocks the neurons, and they must tinker with the formulation to prolong the effects of the drugs. Both Bean and Woolf are confident they’ll succeed.“Eventually, this method could completely transform surgical and post-surgical analgesia, allowing patients to remain fully alert without experiencing pain or paralysis,” says Woolf. “In fact, the possibilities seem endless. I could even imagine using this method to treat itch, as itch-sensitive neurons fall into the same group as pain-sensing ones.”Research in the Woolf lab is supported by the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Dental and Craniofacial Research. Research in the Bean lab is supported by NINDS and the National Institute of General Medical Sciences.Harvard and MGH have filed patents on this technology platform.For a copy of the paper: [email protected]last_img read more

Lenten Chapel Crawl enhances student faith

first_imgWith the season of Lent in full swing at Notre Dame, the Notre Dame Lenten Chapel Crawl, sponsored by Howard Hall, provides students with a unique opportunity to bolster their faith lives while exploring different spiritual communities on campus.Sophomore Cara Lucas, Howard’s liturgical commissioner and one of the Chapel Crawl organizers, said the event features Mass every day of Lent in a different campus chapel.“It’s a chance for students throughout campus to visit all the other dorm chapels,” Lucas said. “We think it’s a thing that’s on a lot of people’s bucket list, so we kind of offer it as a chance to cross something off your Notre Dame bucket list.“Doing it during Lent gives people the chance to do something extra instead of giving something up.”Lucas said hosting the event during Lent also gives students an opportunity to relax and pray as their schedules become hectic.“I think having it during Lent is a good time to reflect,” she said. “Some of the homilies are really helpful to hear, especially when school gets stressful. So instead of wasting an hour on the internet, I like the opportunity to spend that hour in Mass with fellow students.”Sophomore Grace Maginn said she plans on attending all of the Chapel Crawl Masses as a way to enrich her faith life during the Lenten season.“I wanted to pick one Lenten resolution where I gave something up, and another where I actually went out and did something,” Maginn said. “The Chapel Crawl gives me an opportunity to try and attend daily Mass more often.“I try and go a couple days a week, but the chapel crawl posed a new kind of challenge for me, going to Mass even when I feel like I don’t have time for it.”Maginn said the Chapel Crawl offers a community similar to Sunday night dorm Masses, but with a fresh change of scenery.“The chapel crawl is kind of like a travelling Sunday dorm Mass community,” she said. “It’s a big enough group that you feel like the volume levels should be those for a Sunday Mass, so it isn’t your typical daily Mass experience in that sense.“On the other hand, the group is still small enough that I feel like by the end of it I will have made a friend or two.”Although she acknowledged social and prayer life at Notre Dame can grow too comfortable and monotonous, Maginn said the Chapel Crawl allows her and others to leave their comfort zone and encounter new people and faith communities.“The chapel crawl gives me a chance to go to dorms I would never normally visit because, among a number of typical excuses I give, they’re too far away, it’s too cold outside or I don’t know anyone who lives there,” she said. “The chapel crawl allows me to see so many different sides of campus.”Lucas said approximately 70 people attended the kick-off Mass in Howard, and she hopes to see a strong community continue throughout the entire season of Lent.“Last year, toward the end [of Lent], there would only be like two or three Howard girls at Chapel Crawl Masses, so this year we put up posters and made a Facebook page to try to make it a more campus-wide thing,” she said.Lucas said students can find a schedule for Chapel Crawl Masses on the event’s Facebook page and on the Campus Ministry website. Tags: Chapel Crawl, Lentlast_img read more

Welcome Weekend activities introduce students to ND life

first_imgTuesday, approximately 2,000 people from across the country and around the world will be walking into their first classes as college students at Notre Dame.But first, the Division of Student Affairs and First Year of Studies is hosting a variety of activities and programming throughout the weekend to help first year students — and their parents — acclimate. “Welcome Weekend,” previously known as “Frosh-O” or “Freshman Orientation” officially began Friday at 9 a.m., when the first round of freshmen started moving into their dorms. “It’s not orientation anymore — it’s a welcoming,” Maryanne Fisher, Welcome Weekend co-captain for Walsh Community in Pangborn Hall, said. “Throughout the whole first year you’re being welcomed into the community. It’s not like you’re on your own after this weekend; it’s a gradual process to get to know Notre Dame and you’re continually being welcomed.”Last year, an oversight committee redesigned freshman orientation weekend to “streamline” the process of introducing students to Notre Dame without overwhelming them with long speeches or unnecessary information.“The things students should take the most out of this [weekend] is their dorm community: getting to see those faces for the first time, knowing who’s available when you need help,” Flaherty Hall Welcome Weekend co-captain Aline Irihamye said. “It’s just about getting excited for the next four years because it’s a good time and you want it to start off with a blast.” While freshmen are busy getting to know other students and learning their way around campus, information about financial aid, study abroad and the career center will be presented to their parents. The “parent orientation” that runs alongside Welcome Weekend was first introduced last year.Irihamye said one of the biggest changes to this year’s Welcome Weekend was extending weekend programming to Monday.“One of the things that’s being added on this year is the Day of Community, which is on the Monday before classes start,” she said. “Every dorm has a local community organization that they’re going to visit; Flaherty’s is the Center for the Homeless. So from 10 a.m. to 3 p.m., the orientation committee has buses arranged to take students there and bring them back so that from the moment they get here they can see how to get involved.” In addition to encouraging students to become involved in the community, the day is intended to help break what many refer to as the “Notre Dame bubble.” “It’s just to get the first years out in the community,” Fisher said. “A lot of people never really go into South Bend, so it’s just introducing them to things they can do there.” Other community partners participating in the Day of Community include the Food Bank of Northern Indiana, Good Shepherd Montessori School, La Casa de Amistad, the Robinson Community Learning Center, Riverbend Cancer Services and South Bend Parks and Recreation, among others.  The McDonald Center for Student Well-Being and RecSports are also adding to the weekend’s programming with a wellness run and yoga on South Quad each morning of Welcome Weekend, Irihamye said. Fisher said for the most part, programming hasn’t changed much from last year. According to information provided on the Welcome Weekend mobile app, like last year, freshmen will have their first class for the Moreau First-Year Experience Course on Saturday, and will attend DomerFest — a dance party, festival and Notre Dame tradition — that night. The First Year Mass will be held 10 a.m. Sunday at Purcell Pavilion, followed by the first class trip to the Grotto on Sunday night. University President Fr. John Jenkins will also deliver a welcome address to freshmen. The Moreau First Year Experience Course was introduced for the 2015-2016 academic year to continue the orientation process after Welcome Weekend ends. “I wish we would have had [Moreau],” Fisher said. “I think the continued welcoming of students into the community throughout the year is really important.”The Welcome Weekend mobile app was launched last year and features a schedule of events and self-guided campus tours covering academic buildings, favorite study spots and the “best kept secrets” of Notre Dame. The app also has a guide to stores and restaurants in the South Bend area. In addition to the main events of Welcome Weekend, a number of optional programming events are available to students, including academic exploration sessions, a multicultural reception, an interfaith welcome and a performing arts showcase. Additionally, time is set aside each night for residence hall programming. “The main thing [of Welcome Weekend] is welcoming first year students into their dorm community,” Irihamye said. Each dorm was required to make a video to introduce freshmen to the building and community. Irihamye said the video requirement was useful considering the current residence hall arrangement: Flaherty Hall is a new women’s hall that will house all of the former residents of Pangborn Hall, as well as students picked by application. Meanwhile, residents of Walsh Hall — including incoming freshmen — will be living in Pangborn Hall while their building is under renovation. “I know it was confusing for us when we got the email, so I don’t even know what the freshmen think,” Fisher said. “We got to explain [with the video] that we’re Walsh but we’re living in Pangborn for a year. They’re mostly just to show freshmen a little of what they should expect of where they’re living.” While Flaherty Hall is a brand-new dorm, Irihamye said the staff still want to emphasize that first year students are being welcomed into a “strong and close community.”“We’re trying to use the newness of our dorm to our advantage,” she said. “There’s so many ways we can be involved now in forming new traditions and signature events. People should take advantage of that rather than be wary or concerned.”Fisher said the central part of Welcome Weekend is to make new students feel comfortable in their new community and new home. “Notre Dame is a great place, but college can be really scary,” Fisher said. “Welcome Weekend is a really overwhelming experience, but we’re trying to do it in a fun way and get their mind off of leaving home.”Tags: Freshman Orientation 2016, Welcome Weekendlast_img read more

People’s United Community Foundation awards $45,000 in funding

first_imgPeople’s United Bank,Vermont Business Magazine The People’s United Community Foundation, the philanthropic arm of People’s United Bank, has announced today that it has awarded $2,500 to Mobius for their Quality Mentoring System (QMS). This brings the Foundations giving in Vermont during February to $45,000, including the Graham Emergency Shelter, Samaritan House, Zack’s Place, The Mentor Connector, and the Vermont Foodbank.QMS is a national evaluation system developed by MENTOR (The National Mentoring Partnership) to ensure that mentoring programs are meeting all of the best practices in the Elements of Effective Practice for Mentoring. In collaboration with Vermont mentoring programs, Mobius – a statewide nonprofit supporting more than 140 adult-to-youth mentoring program sites serving 2,300 mentor pairs – has adjusted this national system to fit the local needs of the Vermont mentoring community.In order to qualify for funding through the Vermont Mentoring Grants, programs must successfully complete the QMS every three years. Mobius works collaboratively with program staff throughout the year to complete this process.“We are proud to partner with People’s United to bolster the important work that mentoring programs are doing across Vermont,” said Mobius Executive Director Chad Butt. “This grant will help us to ensure that mentors are well supported and that youth are receiving the full evidence-based benefits of having a mentor.“Mobius is an incredible resource in our community,” said Michael Seaver, Officer, People’s United Community Foundation and President, People’s United Bank, Vermont.  “With their Quality Mentoring System, we can feel confident that our mentoring agencies are maintaining high standards for their programs.”It also has awarded $5,000 to John W. Graham Emergency Shelter Services Inc. of Vergennes.The funding brings the total grant amount from People’s United Community Foundation to the organization to $17,000.Since 1980, the John Graham Shelter has served individuals and families as Addison County’s only full-time homeless service provider. The organization provides food, shelter, and housing, support services to help transform lives, and prevention and intervention for people in crisis to address the complex issues that clients face in order to attain permanent housing.People’s United Community Foundation also has awarded $10,000 to Samaritan House in St. Albans.Samaritan House assists homeless individuals and families in obtaining sustainable housing by providing temporary shelter, transitional housing and collaborative support services within the counties of Franklin and Grand Isle. The grant from People’s United Community Foundation will fund housing and support services such as rental subsidies, job training and development, budgeting and credit repair assistance.The funding brings the total amount given to the organization by People’s United Community Foundation to more than $42,000.“This much-needed donation from People’s United Community Foundation will allow us to help folks transition out of homelessness and into permanent housing and self-sufficiency,” said Linda Ryan, Executive Director, Samaritan House.“Samaritan House offers critical support to individuals and families throughout Franklin and Grand Isle Counties,” said Michael Seaver. “We are proud to continue our role as a community partner in helping Vermonters obtain and maintain permanent housing and the necessary skills and resources to become self-reliant.”“Having a warm place to lay your head at night is something many of us take for granted,” said Michael Seaver, Officer, People’s United Community Foundation and President, People’s United Bank Vermont. “Unfortunately, the fastest growing homeless population throughout America is our children. We are pleased to continue our support for the important work of caring shelters like John W. Graham, which ensure that there is a warm place for everyone.”“In the past year, we have had a lot of success in helping homeless families find housing. Now we want to give them the support they need to keep their apartments and remain permanently housed,” said Elizabeth Ready, Executive Director, John W. Graham Emergency Shelter. “We plan to work with families on an ongoing basis to make sure that they have housing well into the future.” The People’s United Community Foundation has also announced that it has awarded $3,000 to Zack’s Place Enrichment Center of Woodstock.Zack’s Place provides people of all ages with special needs opportunities for community engagement, education, vocational programs, and recreational activities. The funding from People’s United Community Foundation will support the ZP Greeting Card Business, which teaches clients art, computer, writing, reading, marketing, and a variety of other skills.“Our participants are crafting a product that they can share with friends, family, and the community, aiding in their job skill development and increasing their self-confidence,” said Dail Frates, Executive Director, Zack’s Place Enrichment. “By creating and selling their own greeting cards, they are able to experience a business model from beginning to end and carry the skills over into job positions in the community.”“Individuals are learning valuable job skills through the greeting card business program,” stated Michael Seaver.  “We are pleased to support a program that is uncovering hidden abilities and aiding in the creation of part-time employment for these individuals.” It also has awarded $3,500 to The Mentor Connector in Rutland, Vermont.The Mentor Connector, a formal mentoring program, pairs youngsters in the Rutland area with adult mentors of the same community.  Mentors and mentees are matched according to their similar interests and the mentor becomes a trusted adult friend with a long-term, consistent commitment to provide guidance and support.The funding brings the total grant amount awarded by People’s United Community Foundation to the organization to $19,000.“Peoples United Community Foundation makes the ongoing support to mentors and their mentees possible and we are so grateful for the continued assistance that helps local youth learn skills involved with everyday life, things we refer to as ‘soft skills,” said Christopher Hultquist, Executive Director, The Mentor Connector.  “This is one-on-one attention and guidance in the specific areas of need and mentees also get assistance with career exploration and college opportunities.”“We are pleased to continue to assist The Mentor Connector in their efforts to bring in additional mentors for their Dropout Prevention program,” said Michael Seaver. “We have been longtime supporters of mentor programs throughout Vermont as it is critical in these times that our future citizens are prepared to succeed.”Earlier this month, the People’s United Community Foundation announced that it had awarded $20,000 to the Vermont Foodbank for the purchasing and distribution of food.The Vermont Foodbank was founded in 1986 in response to an increased need for emergency food assistance among low-income households in central Vermont.  At that time, the Vermont Foodbank distributed to eight food shelves in the central Vermont area.  Today, there are 225 network partners statewide that receive food from the Vermont Foodbank for local distribution.The grant brings the total amount awarded by People’s United Community Foundation to the organization to $120,000.“The donation from People’s United Community Foundation will help the Foodbank continue to provide food to thousands of our Vermont neighbors in need,” said John Sayles, CEO of the Vermont Foodbank.  “We are so grateful for the steadfast support and partnership of the People’s United Community Foundation, which has acted as a constant and strong voice in the fight against hunger.”Demand for charitable food had never been greater. In fact, the Vermont Foodbank distributed nearly ten million pounds of food to 153,000 people in need in 2015.  This year, one in four Vermonters is expected to access a food shelf or meal site at some point.“Many of us take for granted that we can walk into a grocery store and purchase what we need for the week or even just the day,” said Michael Seaver.  “We are pleased to be able to continue our partnership with the Vermont Foodbank and provide $20,000 to aid in securing and distributing healthy food for Vermonters in need.”Established in 2007, People’s United Community Foundation was formed to help support programs and activities that enhance the quality of life for citizens in the communities that People’s United Bank serves. People’s United Bank, founded in 1842 and serving customers from New York to Maine through a network of more than 400 branches, is the largest independent bank headquartered in New England. The Foundation places special emphasis on programs designed to promote economic self-sufficiency, education and improved conditions for low-income families and neighborhoods. The funding priorities of the Foundation include community development, youth development, and affordable housing.Source: People’s United Community Foundationlast_img read more

Oxylane (Décathlon) buys 25% stake in Storck Bicycle

first_imgOxylane Group, the parent company of European sports retailing giant Décathlon, is continuing its acquisition path, with further investments in other sporting goods companies. After buying a share in a French specialist scuba diving retailer, Au Vieux Plongeur, Oxylane has now acquired a minority stake in Germany’s Storck Bicycle.Founded in 1995 in Bad Camberg, Germany, Storck has established itself as a key player in bicycle design and innovation, garnering multiple awards from cycling publications and at Eurobike’s annual design competition.Oxylane has taken a 25% stake in Storck. Founders Markus and Helena Storck have increased their stake in the company from 62.4% to 75%, ensuring a consolidation of ownership.According to Markus Storck, the major shareholder of the eponymous company, the additional financing brought by Oxylane will help it support annual growth of more than 20%. The investment will also be used to develop the Storck brand and to invest in logistics.Day-to-day operations will remain unchanged, Markus Storck added; “Storck Bicycle will continue as an independent company. Our store concept will expand worldwide with dealers and distribution partners. Moreover we expanded our management team.”It is understood that no synergies are planned with Décathlon, whose bicycles are positioned in a lower segment of the market – in contrast with the premium/high-end positioning for Storck bikes.According to reports, in addition to the Storck investment, Oxylane has also acquired shares in a multisport retailer in India, Sport XS; and an online retailer in Japan, Naturum, which specializes in fishing, outdoor and other sports.www.decathlon.com www.storck-bicycle.de Relatedlast_img read more

News Scan for Jul 07, 2017

first_imgMore babies born in the US with Zika-related birth defectsAccording to the latest numbers from the Centers for Disease Control and Prevention (CDC), there are now 88 babies born in the United States with Zika-related birth defects, an increase of 8 since the last report. The number of pregnancy losses showing Zika-related birth defects remains at 8.The numbers are updated through Jun 27. A total of 1,687 Zika-affected pregnancies with or without birth defects have been documented in the United States since 2016. In the US territories, including Puerto Rico, the corresponding number is 2,830; this includes 122 infants with birth defects and 6 pregnancy losses.The numbers reflect only laboratory-confirmed Zika infections in pregnancies registered with the US Zika Pregnancy Registry.Jul 6 CDC update  China’s weekly H7N9 total declines to single caseChina reported just one H7N9 avian influenza case this week, down sharply from six reported the previous week, Hong Kong’s Center for Health Protection (CHP) said today in its weekly update.The patient is a 35-year-old man from Xinjiang Uygur Autonomous Region in the far northwest of the country who began having symptoms on Jun 23 and died on Jun 30. An investigation into the source of his exposure to the virus found that he had sold and slaughtered chickens at a market.Xinjiang has reported a few H7N9 cases in the past, but not in the recent wave of activity, which has been marked by a wide geographic spread of detections in poultry and in people.China has had more than 750 cases in the fifth and largest wave of infections, at least 209 of them fatal.Jul 7 CHP updateIn other H7N9 developments, Chinese researchers who compared recent human infections with highly and low-pathogenic H7N9 in Guangdong province found that clinical outcomes were similar, though people sickened by the highly pathogenic form had longer hospitalizations. The team reported their findings yesterday in the latest issue of Eurosurveillance.Their analysis included 9 patients infected with highly pathogenic H7N9 and 51 who had been sickened by the low-pathogenic strain.Researchers also assessed poultry market environmental surveillance, finding that the touching of sick or dead poultry was the most important risk factor for contracting highly pathogenic H7N9, hinting that because that form of the virus disseminates to multiple organs, including muscle, handling sick birds could be more risky. Raising backyard poultry and touching live poultry were also risk factors.They concluded that it’s still not possible to tell if highly pathogenic H7N9 causes more severe disease in humans, but detailed investigations about shedding, virus dissemination, and inflammation levels are needed to shed more light. They also noted that investigation of the impact of the virus on chickens is urgently needed.Jul 6 Eurosurveill report Washington state hantavirus cases rise to fiveWashington state reported another hantavirus infection, raising the season’s total to five, the most since 1999, the Washington State Department of Health (WSDH) said yesterday in a press release.The illnesses are from four counties, Franklin, King, Spokane, and Skagit, and three deaths occurred among the cases.Deer mice are known to carry hantavirus, which can spread to humans through contaminated air or direct contact with the animals or their saliva, urine, droppings, or nesting material, the WSDH said.In its background materials on the disease, the department said 1 to 5 cases are typically reported each year, and about 1 in 3 people who have hantavirus pulmonary syndrome die.Jul 6 WSDH press release WSDH hantavirus background Jun 28 CIDRAP News scan “Washington state reports fourth hantavirus case of the year” CDC warns of meningitis risk in vaccinated patients on SolirisThe CDC today issued a Health Alert Network (HAN) advisory warning about a high risk of meningococcal disease despite vaccination in patients who are being treated with Soliris (eculizumab), a monoclonal antibody used to treat rare blood diseases including atypical hemolytic uremic syndrome and paroxysmal nocturnal hemoglobinuria.Patients taking the drug are known to be at 1,000- to 2,000-fold greater risk of meningococcal disease, and Soliris comes with a warning that those on the medication should be vaccinated.The CDC said that between 2008 and 2016 it has identified 16 cases of meningitis in eculizumab recipients, 11 of whom had nongroupable Neisseria meningitidis, which isn’t covered by the MenA conjugate vaccine. The newly approved meningococcal B vaccine protects only against that strain. The CDC detailed the findings and concerns today in an early release report in Morbidity and Mortality Weekly Report (MMWR). They said researchers haven’t assessed the extent of any cross-protection for nongroupable N meningitidis strains.In today’s HAN, the CDC urged health providers to consider antimicrobial prophylaxis for the duration of eculizumab treatment and to continue to vaccinate patients who are on the medication, administering the first dose at least 2 weeks before starting treatment when possible. They also recommended that clinicians keep a high index of suspicion for meningococcal disease in patients who are taking eculizumab.Jul 7 CDC HAN notice Jul 7 MMWR reportlast_img read more

Slot Canyon Trail At Kasha-Katuwe Tent Rocks National Monument To Undergo Trail Maintenance July 22-24

first_imgKasha-Katuwe Tent Rocks National Monument. Courtesy photo BLM News: ALBUQUERQUE ― The Bureau of Land Management is announcing a partial closure of the Slot Canyon Trail at Kasha-Katuwe Tent Rocks National Monument.  Like other monuments and public lands across the nation, the Monument has seen significant increase in visitation over the last five years. So far, in 2019, the Monument has had over 80,000 visitors. The BLM, in partnership with Pueblo de Cochiti, is currently researching additional ways to protect the Monument’s unique resources and the visitor experience through alternate visitor use management strategies. The decision to limit access in this area for maintenance is consistent with the BLM’s ongoing communication with the Pueblo.   Due to the exposure, weather and consistent foot traffic, this section of trail is showing signs of erosion, making foot travel more difficult for visitors. The lower section of the Slot Canyon Trail will remain open to the public, as will the Memorial Overlook Loop Trail. The necessary trail improvements will be conducted July 22-24 on the last half-mile section of the Slot Canyon Trail that climbs steeply out of the canyon to the mesa top. By providing these trail improvements, the BLM is striving to protect the fragile geologic features of this area and increase visitor safety.   For more information, or to inquire about alternate recreational opportunities in the area, please contact BLM Outdoor Recreation Planner Jamie Garcia at 505.761.8787.last_img read more

NSCC survey of specialists highlights strategic industry problems

first_imgGet your free guest access  SIGN UP TODAY Subscribe now for unlimited access Stay at the forefront of thought leadership with news and analysis from award-winning journalists. Enjoy company features, CEO interviews, architectural reviews, technical project know-how and the latest innovations.Limited access to building.co.ukBreaking industry news as it happensBreaking, daily and weekly e-newsletters To continue enjoying Building.co.uk, sign up for free guest accessExisting subscriber? LOGIN Subscribe to Building today and you will benefit from:Unlimited access to all stories including expert analysis and comment from industry leadersOur league tables, cost models and economics dataOur online archive of over 10,000 articlesBuilding magazine digital editionsBuilding magazine print editionsPrinted/digital supplementsSubscribe now for unlimited access.View our subscription options and join our communitylast_img read more

Unclear nuclear

first_imgTo continue enjoying Building.co.uk, sign up for free guest accessExisting subscriber? LOGIN Stay at the forefront of thought leadership with news and analysis from award-winning journalists. Enjoy company features, CEO interviews, architectural reviews, technical project know-how and the latest innovations.Limited access to building.co.ukBreaking industry news as it happensBreaking, daily and weekly e-newsletters Subscribe now for unlimited access Get your free guest access  SIGN UP TODAY Subscribe to Building today and you will benefit from:Unlimited access to all stories including expert analysis and comment from industry leadersOur league tables, cost models and economics dataOur online archive of over 10,000 articlesBuilding magazine digital editionsBuilding magazine print editionsPrinted/digital supplementsSubscribe now for unlimited access.View our subscription options and join our communitylast_img read more

IMCA seminar to focus on cranes

first_imgThe seminar, which will be held at the Novotel Hotel, will focus on all aspects of offshore cranes for a range of applications including subsea, wind energy, heavy lift and decommissioning. It will also look at the future of subsea lifting. Mark Ford, IMCA’s technical manager, said: “The Lifting and Rigging seminar is a great way for delegates to get involved in discussions on issues affecting the industry. It’s an opportunity to identify common issues and needs for offshore contractors, which can feed into future strategies and guidelines for improvements.” The seminar is aimed at subsea contractors, offshore crane designers/manufacturers, equipment suppliers, crane training and academic institutions. It will feature a combination of presentations and workshop sessions, with a focus on facilitating discussion between contractors, suppliers and research institutes. TechnipFMC’s David Cannell, chairman of the event, said: “We have a great agenda and important contributions from major industry contractors, operators and suppliers. “It’s also an opportunity for delegates to hear about some of the latest technology and thinking on crane operations with presentations from top academic and training institutions.”  www.imca-int.comlast_img read more