Naphthoquine-azithromycin shows efficacy against malaria in phase 3 trialA phase 3 clinical trial involving 531 people living along the China-Myanmar border has shown that the antimalarial-antibacterial drug combination naphthoquine-azithromycin (NQAZ) is effective in preventing malarial Plasmodium infections.Plasmodium species are parasites that spread bacteria to vertebrates via blood-sucking insects such as mosquitoes. The trial, published yesterday in Clinical Infectious Diseases, found that only 3 of 319 volunteers (0.9%) in the group receiving NQAZ tablets tested positive for falciparum malaria on blood smear, versus 46 of 312 (14.7%) in the placebo group.In an intent-to-treat analysis, single-dose monthly NQAZ had a prophylactic effectiveness of 93.6% against malarial Plasmodium (95% confidence interval [CI], 91.7% to 95.5%). A per-protocol analysis showed that NQAZ had 93.0% effectiveness (95% CI, 91.0% to 95.1%).NQAZ prevented 100% of infections from relapsing malaria caused by Plasmodium vivax and P ovale. Among subjects receiving NQAZ, 5.6% had short-term elevations of liver transaminases (indicating liver damage), compared with 2.2% of the placebo group (P > 0.05).”Monthly prophylaxis with NQAZ tablets was well tolerated and highly effective for preventing Plasmodium infections,” they wrote. “It may prove useful for eliminating P. vivax in areas with a high prevalence of glucose-6-phosphate dehydrogenase deficiency in the population,” a condition that causes red blood cells to rupture and die.Jul 20 Clin Infect Dis abstract WHO: global flu levels low for this time of yearGlobal flu activity is lower than expected for this time of year, and the flu season hasn’t started in the Southern Hemisphere, which is in the midst of its winter season, the World Health Organization (WHO) said yesterday in a regular update. It included the caveats that the COVID-19 pandemic may be affecting health behaviors and testing capacity.Sporadic flu detections were reported in the Caribbean and Central American regions, though severe acute respiratory infection (SARI) activity is elevated in some countries, which likely reflects COVID-19 activity.Tropical parts of South America and Africa also reported sporadic flu cases, but no flu detections were reported in Southern Asia or Southeast Asia. In the Northern Hemisphere, flu remained at interseasonal levels.New Zealand reports slight increases in flulike illness and SARI for June, but flu positives were low for this time of year, with other respiratory viruses such as rhinovirus found in tested samples.Of specimens tested through roughly the last part of June and into the first week of July, 43 were positive for flu, with influenza A and influenza B equally represented. The one subtyped influenza A virus was 2009 H1N1.Jul 20 WHO global flu update
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Walter LegerLeger will serve a five-year term on the seven-member board, succeeding Arnold Baker.The port commissioners also serve as directors of the New Orleans Public Belt Corporation (NOPB), a Port NOLA subsidiary.www.portnola.com
Australia’s GrainCorp has awarded Watco a contract to provide haulage services on the 1 067 mm gauge network in Queensland, where two harvests per year produce 2·8 millions of tonnes of grain. Watco has ordered eight locomotives from US supplier National Rail Equipment, as well as wagons from China, and plans to start operations in Q4 2019.Approval has been granted for the transport of dangerous goods on the standard gauge railway between Mombasa and Nairobi.3Squared has won a contract to provide four of its RailSmart suite of 13 business applications to Hector Rail. The contract initially covers the RailSmart CL collaborative control log, RailSmart FD defect reporting app, RailSmart MCA digital train consist and the RailSmart Employee Development System, with the roll-out of the full RailSmart system planned.United Wagon Co’s TikhvinSpetsMash factory has supplied 162 Type 13-6852-02 timber wagons to Estonian freight operator Operail’s wagon leasing subsidiary WagonPro. The 25 tonne axleload wagons offer a capacity of 74 tonnes or 122 m3, with overhaul intervals of 800 000 km or eight years comparing favourably to the 210 000 km or three years of older designs.GEFCO and Bergé have formed an alliance to provide finished vehicle logistics services for the automotive sector in Spain. The equally-owned company will have the capacity to handle 1·4 million cars annually, with more than 100 railway wagons and 700 lorries as well as 10 logistic centres.The City of Oshkosh, Greater Oshkosh Economic Development Corp and Watco’s Wisconsin & Southern Railroad have opened a terminal in the Wisconsin city which has two 400 m sidings serving local industrial customers.JSW Steel has extended until the end of August 2022 a contract under which India’s South Western Railway gives a tariff rebate in return for assured tonnages of freight from plants at Tornagallu to Dolvi (Mumbai) and Salem.
Play VideoPlayMuteCurrent Time 0:00/Duration Time 0:00Loaded: 0%0:00Progress: 0%0:00 Progress: 0%Stream TypeLIVERemaining Time -0:00 Playback Rate1ChaptersChaptersdescriptions off, selectedDescriptionssubtitles off, selectedSubtitlescaptions settings, opens captions settings dialogcaptions off, selectedCaptionsAudio TrackFullscreenThis is a modal window. The Video Cloud video was not found. Error Code: VIDEO_CLOUD_ERR_VIDEO_NOT_FOUND Session ID: 2020-09-18:142c614f78494de23dae2be Player ID: videojs-brightcove-player-770454-3916244825001 OK Close Modal DialogCaption Settings DialogBeginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsDefaultsDoneClose Modal DialogThis is a modal window. This modal can be closed by pressing the Escape key or activating the close button.Mississippi State coach Dan Mullen speaks to the media after his team’s 31-17 loss to Ole Miss in the Egg Bowl.